Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury

A. S. Gorbunov, O. E. Vaizova, M. V. Belousov, S. V. Pozdnyakova, E. A. Nesterov, P. G. Madonov

Research output: Contribution to journalArticle

Abstract

Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume164
Issue number1
DOIs
Publication statusAccepted/In press - 9 Nov 2017

Fingerprint

Narcotic Antagonists
Opioid Receptors
Reperfusion Injury
Rats
Chloralose
Naltrexone
Intravenous Injections
Chemical activation
Myocardial Infarction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury. / Gorbunov, A. S.; Vaizova, O. E.; Belousov, M. V.; Pozdnyakova, S. V.; Nesterov, E. A.; Madonov, P. G.

In: Bulletin of Experimental Biology and Medicine, Vol. 164, No. 1, 09.11.2017, p. 1-3.

Research output: Contribution to journalArticle

@article{1c065f0a4e364353997e484121d20314,
title = "Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury",
abstract = "Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.",
author = "Gorbunov, {A. S.} and Vaizova, {O. E.} and Belousov, {M. V.} and Pozdnyakova, {S. V.} and Nesterov, {E. A.} and Madonov, {P. G.}",
year = "2017",
month = "11",
day = "9",
doi = "10.1007/s10517-017-3916-6",
language = "English",
volume = "164",
pages = "1--3",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury

AU - Gorbunov, A. S.

AU - Vaizova, O. E.

AU - Belousov, M. V.

AU - Pozdnyakova, S. V.

AU - Nesterov, E. A.

AU - Madonov, P. G.

PY - 2017/11/9

Y1 - 2017/11/9

N2 - Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.

AB - Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.

UR - http://www.scopus.com/inward/record.url?scp=85033402967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033402967&partnerID=8YFLogxK

U2 - 10.1007/s10517-017-3916-6

DO - 10.1007/s10517-017-3916-6

M3 - Article

VL - 164

SP - 1

EP - 3

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -