Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury

Abstract

Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ₁-OR antagonist BNTX (0.7 mg/kg), selective δ₂-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	164
Issue number	1
DOIs	https://doi.org/10.1007/s10517-017-3916-6
Publication status	Accepted/In press - 9 Nov 2017

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Gorbunov, A. S., Vaizova, O. E., Belousov, M. V., Pozdnyakova, S. V., Nesterov, E. A., & Madonov, P. G. (Accepted/In press). Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury. Bulletin of Experimental Biology and Medicine, 164(1), 1-3. https://doi.org/10.1007/s10517-017-3916-6

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title = "Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury",

abstract = "Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.",

author = "Gorbunov, {A. S.} and Vaizova, {O. E.} and Belousov, {M. V.} and Pozdnyakova, {S. V.} and Nesterov, {E. A.} and Madonov, {P. G.}",

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AU - Gorbunov, A. S.

AU - Vaizova, O. E.

AU - Belousov, M. V.

AU - Pozdnyakova, S. V.

AU - Nesterov, E. A.

AU - Madonov, P. G.

PY - 2017/11/9

Y1 - 2017/11/9

N2 - Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.

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