Abstract
The role of KATP channels in myocardial infarct size-limiting effect of chronic continuous normobaric hypoxia was examined in a rat model based on a 20-min coronary occlusion and subsequent 3-h reperfusion. Rats were adapted to normobaric hypoxia (12% O2) for 21 days. This hypoxia produced a pronounced infarct size-limiting effect, which had been prevented by 0.3 mg/kg glibenclamide, a non-selective inhibitor of entire pool of KATP channels, or 5 mg/kg 5-hydroxydecanoate, an inhibitor of mitochondrial KATP channels. The study highlighted the important role of mitochondrial KATP channels in myocardial infarct size-limiting effect of chronic normobaric hypoxia.
| Original language | English |
|---|---|
| Pages (from-to) | 1-3 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 163 |
| Issue number | 1 |
| DOIs | |
| Publication status | Accepted/In press - 2 Jun 2017 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Lishmanov, Y. B., Naryzhnaya, N. V., Tsibul’nikov, S. Y., Wang, H., & Maslov, L. N. (Accepted/In press). Role of ATP-Sensitive K+ Channels in Myocardial Infarct Size-Limiting Effect of Chronic Continuous Normobaric Hypoxia. Bulletin of Experimental Biology and Medicine, 163(1), 1-3. https://doi.org/10.1007/s10517-017-3728-8