Role of ATP-Sensitive K+ Channels in Myocardial Infarct Size-Limiting Effect of Chronic Continuous Normobaric Hypoxia

Y. B. Lishmanov, N. V. Naryzhnaya, S. Y. Tsibul’nikov, H. Wang, Leonid N. Maslov

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Abstract

The role of KATP channels in myocardial infarct size-limiting effect of chronic continuous normobaric hypoxia was examined in a rat model based on a 20-min coronary occlusion and subsequent 3-h reperfusion. Rats were adapted to normobaric hypoxia (12% O2) for 21 days. This hypoxia produced a pronounced infarct size-limiting effect, which had been prevented by 0.3 mg/kg glibenclamide, a non-selective inhibitor of entire pool of KATP channels, or 5 mg/kg 5-hydroxydecanoate, an inhibitor of mitochondrial KATP channels. The study highlighted the important role of mitochondrial KATP channels in myocardial infarct size-limiting effect of chronic normobaric hypoxia.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume163
Issue number1
DOIs
Publication statusAccepted/In press - 2 Jun 2017

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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