Role of ATP-Sensitive K⁺ Channels in Myocardial Infarct Size-Limiting Effect of Chronic Continuous Normobaric Hypoxia

Y. B. Lishmanov, N. V. Naryzhnaya, S. Y. Tsibul’nikov, H. Wang, Leonid N. Maslov

Research Nuclear Reactor Center

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Abstract

The role of K_ATP channels in myocardial infarct size-limiting effect of chronic continuous normobaric hypoxia was examined in a rat model based on a 20-min coronary occlusion and subsequent 3-h reperfusion. Rats were adapted to normobaric hypoxia (12% O₂) for 21 days. This hypoxia produced a pronounced infarct size-limiting effect, which had been prevented by 0.3 mg/kg glibenclamide, a non-selective inhibitor of entire pool of K_ATP channels, or 5 mg/kg 5-hydroxydecanoate, an inhibitor of mitochondrial K_ATP channels. The study highlighted the important role of mitochondrial K_ATP channels in myocardial infarct size-limiting effect of chronic normobaric hypoxia.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	163
Issue number	1
DOIs	https://doi.org/10.1007/s10517-017-3728-8
Publication status	Accepted/In press - 2 Jun 2017

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ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lishmanov, Y. B., Naryzhnaya, N. V., Tsibul’nikov, S. Y., Wang, H., & Maslov, L. N. (Accepted/In press). Role of ATP-Sensitive K⁺ Channels in Myocardial Infarct Size-Limiting Effect of Chronic Continuous Normobaric Hypoxia. Bulletin of Experimental Biology and Medicine, 163(1), 1-3. https://doi.org/10.1007/s10517-017-3728-8

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10.1007/s10517-017-3728-8