Role of ATP-sensitive K+-channels in antiarrhythmic and cardioprotective action of adaptation to intermittent hypobaric hypoxia

F. Kolar, J. Nekar, B. Ostadal, L. N. Maslov, D. L. Stakheev, A. S. Tayurskaya, Yu B. Lishmanov

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Mature Wistar rats were exposed to intermittent hypobaric hypoxia (5000 m, 6 h/day, 30 sessions). This mode of adaptation enhanced heart tolerance to the arrhythmogenic action of 45-min coronary occlusion, but does not affect the infarction size/risk area ratio. In some series, the rats were exposed to more severe intermittent hypobaric hypoxia (7000 m, 8 h/day, 6 weeks) followed by 20-min coronary occlusion and 3-h reperfusion one day after the last hypoxia session. In this case, adaptation reduced the infarction size/risk area ratio and enhanced cardiac tolerance to the arrhythmogenic effect of reperfusion, but had no effect on the incidence of ventricular arrhythmia during ischemia. We found that the cardioprotective and antiarrhythmic effects of adaptation to an altitude of 7000 m and the antiarrhythmic effect of 5000-m adaptation were mediated via activation of KATP channels.

Original languageEnglish
Pages (from-to)418-421
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume145
Issue number4
DOIs
Publication statusPublished - 1 Apr 2008

Keywords

  • Adaptation
  • Heart
  • Hypoxia
  • Ischemia
  • K channels
  • Reperfusion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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