Role of δ1 Opiate Receptors in Regulation of Contractility in Isolated Rat Heart during Normal Oxygenation and Ischemia/Reperfusion

T. V. Lasukova, L. N. Maslov, Yu B. Lishmanov, G. J. Gross

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The experiments with the isolated rat heart demonstrated a significant decrease in reperfusion-induced damage of cardiomyocytes upon adding the selective δ1 receptor agonist DPDPE (0.1 mg/l) to the perfusion solution. On the contrary, no cardioprotective effect was observed for 0.5 mg/l concentration of the peptide or after its intravenous injection. Stimulation of the cardiac δ1 opioid receptors by intravenous injection of 0.5 mg/kg DPDPE or its addition to the perfusion solution decreased myocardial contractility both under conditions of normal oxygenation and during reperfusion. Thus, the cardioprotective and negative inotropic effect of DPDPE is mediated by activation of the cardiac δ1 opioid receptors.

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalBiology Bulletin
Volume31
Issue number1
DOIs
Publication statusPublished - 1 Jan 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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