Abstract
The 5-year results of the combined modality treatment with the use of neutron-photon therapy for patients with T3-4N0-1M0 locally advanced breast cancer (LABC) are presented. Fifty-three patients with primary locally advanced T3-4N0-1M0 breast cancer received 1-2 courses of neo-adjuvant chemotherapy according to CMF schedule with the standard dosage (42 patients), high-dosage chemotherapy (11 patients) and preoperative radiation therapy with 6.3 MeV neutrons within 8-12 days. Conventional gamma-therapy (total dose of 40-45 Gy) was delivered to the areas of potential regional spread and adjuvant chemotherapy was administered according to CMF schedule for 1.5-2 years. Local recurrences occurred 8 times more rarely in patients of the main group, who received the combined modality treatment applying the preoperative neutron therapy than those in the control group. Five-year recurrence-free survival rates in patients with locally-advanced breast cancer were as follows: 96.3 ± 3.6% in the group with neutron therapy and 80 ± 6.8% in the control group. The overall 5-year survival rates were higher in the main group of patients than those in patients of the control group (66.8 ± 8.5 and 56.5 ± 11.4%, respectively).
| Original language | English |
|---|---|
| Pages (from-to) | 51-58 |
| Number of pages | 8 |
| Journal | Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost' |
| Volume | 49 |
| Issue number | 2 |
| Publication status | Published - 2004 |
| Externally published | Yes |
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Keywords
- Locally advanced breast cancer
- Neutron-photon therapy
- Therapy results
ASJC Scopus subject areas
- Nuclear Energy and Engineering
Cite this
Results of comprehensive neutron and photon therapy of topical breast cancers. / Musabaeva, L. I.; Zhogina, Zh A.; Slonimskaya, E. M.; Lisin, V. A.
In: Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost', Vol. 49, No. 2, 2004, p. 51-58.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Results of comprehensive neutron and photon therapy of topical breast cancers
AU - Musabaeva, L. I.
AU - Zhogina, Zh A.
AU - Slonimskaya, E. M.
AU - Lisin, V. A.
PY - 2004
Y1 - 2004
N2 - The 5-year results of the combined modality treatment with the use of neutron-photon therapy for patients with T3-4N0-1M0 locally advanced breast cancer (LABC) are presented. Fifty-three patients with primary locally advanced T3-4N0-1M0 breast cancer received 1-2 courses of neo-adjuvant chemotherapy according to CMF schedule with the standard dosage (42 patients), high-dosage chemotherapy (11 patients) and preoperative radiation therapy with 6.3 MeV neutrons within 8-12 days. Conventional gamma-therapy (total dose of 40-45 Gy) was delivered to the areas of potential regional spread and adjuvant chemotherapy was administered according to CMF schedule for 1.5-2 years. Local recurrences occurred 8 times more rarely in patients of the main group, who received the combined modality treatment applying the preoperative neutron therapy than those in the control group. Five-year recurrence-free survival rates in patients with locally-advanced breast cancer were as follows: 96.3 ± 3.6% in the group with neutron therapy and 80 ± 6.8% in the control group. The overall 5-year survival rates were higher in the main group of patients than those in patients of the control group (66.8 ± 8.5 and 56.5 ± 11.4%, respectively).
AB - The 5-year results of the combined modality treatment with the use of neutron-photon therapy for patients with T3-4N0-1M0 locally advanced breast cancer (LABC) are presented. Fifty-three patients with primary locally advanced T3-4N0-1M0 breast cancer received 1-2 courses of neo-adjuvant chemotherapy according to CMF schedule with the standard dosage (42 patients), high-dosage chemotherapy (11 patients) and preoperative radiation therapy with 6.3 MeV neutrons within 8-12 days. Conventional gamma-therapy (total dose of 40-45 Gy) was delivered to the areas of potential regional spread and adjuvant chemotherapy was administered according to CMF schedule for 1.5-2 years. Local recurrences occurred 8 times more rarely in patients of the main group, who received the combined modality treatment applying the preoperative neutron therapy than those in the control group. Five-year recurrence-free survival rates in patients with locally-advanced breast cancer were as follows: 96.3 ± 3.6% in the group with neutron therapy and 80 ± 6.8% in the control group. The overall 5-year survival rates were higher in the main group of patients than those in patients of the control group (66.8 ± 8.5 and 56.5 ± 11.4%, respectively).
KW - Locally advanced breast cancer
KW - Neutron-photon therapy
KW - Therapy results
UR - http://www.scopus.com/inward/record.url?scp=4344610859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4344610859&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:4344610859
VL - 49
SP - 51
EP - 58
JO - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
JF - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
SN - 0025-8334
IS - 2
ER -