Relaxivity of Paramagnetic Complexes of Manganese and Gadolinium

O. Yu Borodin, M. Yu Sannikov, M. L. Belyanin, V. D. Filimonov, V. Yu Usov, Yu L. Rybakov, V. M. Gukasov, N. L. Shimanovskii

The Kizhner Research Center

Research output: Contribution to journal › Article

Abstract

The relaxivities of aqueous solutions of the manganese complexes Mn-CDTA, Mn-DTPA, and Mn-EDTA were compared with that of the gadolinium complex Gd-DTPA. Relaxivities R1 and R2 of Mn-CDTA solutions were slightly greater than those of Gd-DTPA. The lowest relaxivities were seen for Mn-DTPA, while Mn-EDTA occupied an intermediate position between Mc-CTDA and Mn-DTPA.

Original language	English
Pages (from-to)	635-637
Number of pages	3
Journal	Pharmaceutical Chemistry Journal
Volume	53
Issue number	7
DOIs	https://doi.org/10.1007/s11094-019-02052-6
Publication status	Published - 1 Oct 2019

Keywords

gadolinium complexes
magnetic resonance imaging
manganese complexes
relaxivity

ASJC Scopus subject areas

Pharmacology
Drug Discovery

Access to Document

10.1007/s11094-019-02052-6

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abstract = "The relaxivities of aqueous solutions of the manganese complexes Mn-CDTA, Mn-DTPA, and Mn-EDTA were compared with that of the gadolinium complex Gd-DTPA. Relaxivities R1 and R2 of Mn-CDTA solutions were slightly greater than those of Gd-DTPA. The lowest relaxivities were seen for Mn-DTPA, while Mn-EDTA occupied an intermediate position between Mc-CTDA and Mn-DTPA.",

keywords = "gadolinium complexes, magnetic resonance imaging, manganese complexes, relaxivity",

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T1 - Relaxivity of Paramagnetic Complexes of Manganese and Gadolinium

AU - Borodin, O. Yu

AU - Sannikov, M. Yu

AU - Belyanin, M. L.

AU - Filimonov, V. D.

AU - Usov, V. Yu

AU - Rybakov, Yu L.

AU - Gukasov, V. M.

AU - Shimanovskii, N. L.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - The relaxivities of aqueous solutions of the manganese complexes Mn-CDTA, Mn-DTPA, and Mn-EDTA were compared with that of the gadolinium complex Gd-DTPA. Relaxivities R1 and R2 of Mn-CDTA solutions were slightly greater than those of Gd-DTPA. The lowest relaxivities were seen for Mn-DTPA, while Mn-EDTA occupied an intermediate position between Mc-CTDA and Mn-DTPA.

AB - The relaxivities of aqueous solutions of the manganese complexes Mn-CDTA, Mn-DTPA, and Mn-EDTA were compared with that of the gadolinium complex Gd-DTPA. Relaxivities R1 and R2 of Mn-CDTA solutions were slightly greater than those of Gd-DTPA. The lowest relaxivities were seen for Mn-DTPA, while Mn-EDTA occupied an intermediate position between Mc-CTDA and Mn-DTPA.

KW - gadolinium complexes

KW - magnetic resonance imaging

KW - manganese complexes

KW - relaxivity

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