Relationship between Sympatico-Adrenal and Opioid Systems as a Factor Determining the Degree of Stress Heart Damage

N. V. Naryzhnaya, L. N. Maslov, Yu H. Revinskaya, Yu B. Lishmanov

Research output: Contribution to journalArticle

Abstract

The present paper has analyzed relationship between sympatico-adrenal and opioid systems in the pathogenesis of stress heart damage. Based on the our own results and other investigator data the authors make a conclusion that namely relationship between opioid and sympatico-adrenal systems both on the level of the brain and on the periphery determinates a degree of the heart resistance to the injury action of severe stress. Myocardial protection by opioids at stress was found to be mediated by the peripheral μ-opioid receptors and was associated with decrease in an activity of sympatico-adrenal system and a inhibition of its effector part. On contrary central opioid system activation leads to an increase in stress heart damage via an increase in sympatical influence on the myocardium.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalUspekhi Fiziologicheskikh Nauk
Volume32
Issue number4
Publication statusPublished - 1 Jan 2001

ASJC Scopus subject areas

  • Physiology

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