Abstract
The present paper has analyzed relationship between sympatico-adrenal and opioid systems in the pathogenesis of stress heart damage. Based on the our own results and other investigator data the authors make a conclusion that namely relationship between opioid and sympatico-adrenal systems both on the level of the brain and on the periphery determinates a degree of the heart resistance to the injury action of severe stress. Myocardial protection by opioids at stress was found to be mediated by the peripheral μ-opioid receptors and was associated with decrease in an activity of sympatico-adrenal system and a inhibition of its effector part. On contrary central opioid system activation leads to an increase in stress heart damage via an increase in sympatical influence on the myocardium.
| Original language | English |
|---|---|
| Pages (from-to) | 78-81 |
| Number of pages | 4 |
| Journal | Uspekhi Fiziologicheskikh Nauk |
| Volume | 32 |
| Issue number | 4 |
| Publication status | Published - 1 Jan 2001 |
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ASJC Scopus subject areas
- Physiology
Cite this
Relationship between Sympatico-Adrenal and Opioid Systems as a Factor Determining the Degree of Stress Heart Damage. / Naryzhnaya, N. V.; Maslov, L. N.; Revinskaya, Yu H.; Lishmanov, Yu B.
In: Uspekhi Fiziologicheskikh Nauk, Vol. 32, No. 4, 01.01.2001, p. 78-81.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between Sympatico-Adrenal and Opioid Systems as a Factor Determining the Degree of Stress Heart Damage
AU - Naryzhnaya, N. V.
AU - Maslov, L. N.
AU - Revinskaya, Yu H.
AU - Lishmanov, Yu B.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The present paper has analyzed relationship between sympatico-adrenal and opioid systems in the pathogenesis of stress heart damage. Based on the our own results and other investigator data the authors make a conclusion that namely relationship between opioid and sympatico-adrenal systems both on the level of the brain and on the periphery determinates a degree of the heart resistance to the injury action of severe stress. Myocardial protection by opioids at stress was found to be mediated by the peripheral μ-opioid receptors and was associated with decrease in an activity of sympatico-adrenal system and a inhibition of its effector part. On contrary central opioid system activation leads to an increase in stress heart damage via an increase in sympatical influence on the myocardium.
AB - The present paper has analyzed relationship between sympatico-adrenal and opioid systems in the pathogenesis of stress heart damage. Based on the our own results and other investigator data the authors make a conclusion that namely relationship between opioid and sympatico-adrenal systems both on the level of the brain and on the periphery determinates a degree of the heart resistance to the injury action of severe stress. Myocardial protection by opioids at stress was found to be mediated by the peripheral μ-opioid receptors and was associated with decrease in an activity of sympatico-adrenal system and a inhibition of its effector part. On contrary central opioid system activation leads to an increase in stress heart damage via an increase in sympatical influence on the myocardium.
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UR - http://www.scopus.com/inward/citedby.url?scp=0042737829&partnerID=8YFLogxK
M3 - Article
VL - 32
SP - 78
EP - 81
JO - Uspekhi Fiziologicheskikh Nauk
JF - Uspekhi Fiziologicheskikh Nauk
SN - 0301-1798
IS - 4
ER -