Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline

Mark B. Plotnikov, Oleg I. Aliev, Alexey V. Nosarev, Alexander Y. Shamanaev, Anastasia V. Sidekhmenova, Yana Anfinogenova, Anna M. Anishchenko, Ekaterina V. Pushkina

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND: Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. OBJECTIVE: The aim of our work was to study the haemodynamic and haemorheologic effects of a treatment course with pentoxifylline (PTX) in SHRs in an effort to assess the impact of the rheological factor on TPR and AP. METHODS: The effects of the treatment course with PTX (100 mg/kg/day p.o. for six weeks) on BV, plasma viscosity, haematocrit, erythrocyte aggregation and deformability, mean AP (MAP), stroke volume (SV), CO, and TPR were studied in SHRs and in control Wistar Kyoto (WKY) rats. RESULTS: PTX-treated SHRs had a lower BV, lower erythrocyte aggregation, and higher erythrocyte deformability index compared with the controls. The TPR level was higher by 43% compared with that in WKY rats and did not differ from the values obtained from control SHRs. In SHRs, moderate and strong positive correlations were found between BV and MAP and between BV and TPR. PTX-treated SHRs did not have any significant correlations between the above mentioned parameters. CONCLUSIONS: Treatment with PTX attenuated whole blood viscosity, but did not affect the AP and hemodynamic parameters in the experimental SHRs compared with the control SHRs. The magnitude of the rheologic effects of PTX was insufficient to cause appreciable decreases in TPR and AP.

Original languageEnglish
Pages (from-to)93-107
Number of pages15
JournalBiorheology
Volume53
Issue number2
DOIs
Publication statusPublished - 12 Aug 2016

Fingerprint

Pentoxifylline
Blood Viscosity
Inbred SHR Rats
Vascular Resistance
Arterial Pressure
Erythrocyte Aggregation
Erythrocyte Deformability
Inbred WKY Rats
Cardiac Output
Hemodynamics
Erythrocyte Indices
Hematocrit
Viscosity
Stroke Volume
Blood Vessels

Keywords

  • Aortic ring tone
  • Arterial blood pressure
  • Blood viscosity
  • Pentoxifylline
  • SHR
  • Total peripheral resistance

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)
  • Physiology (medical)

Cite this

Plotnikov, M. B., Aliev, O. I., Nosarev, A. V., Shamanaev, A. Y., Sidekhmenova, A. V., Anfinogenova, Y., ... Pushkina, E. V. (2016). Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline. Biorheology, 53(2), 93-107. https://doi.org/10.3233/BIR-15100

Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline. / Plotnikov, Mark B.; Aliev, Oleg I.; Nosarev, Alexey V.; Shamanaev, Alexander Y.; Sidekhmenova, Anastasia V.; Anfinogenova, Yana; Anishchenko, Anna M.; Pushkina, Ekaterina V.

In: Biorheology, Vol. 53, No. 2, 12.08.2016, p. 93-107.

Research output: Contribution to journalArticle

Plotnikov, MB, Aliev, OI, Nosarev, AV, Shamanaev, AY, Sidekhmenova, AV, Anfinogenova, Y, Anishchenko, AM & Pushkina, EV 2016, 'Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline', Biorheology, vol. 53, no. 2, pp. 93-107. https://doi.org/10.3233/BIR-15100
Plotnikov, Mark B. ; Aliev, Oleg I. ; Nosarev, Alexey V. ; Shamanaev, Alexander Y. ; Sidekhmenova, Anastasia V. ; Anfinogenova, Yana ; Anishchenko, Anna M. ; Pushkina, Ekaterina V. / Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline. In: Biorheology. 2016 ; Vol. 53, No. 2. pp. 93-107.
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abstract = "BACKGROUND: Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. OBJECTIVE: The aim of our work was to study the haemodynamic and haemorheologic effects of a treatment course with pentoxifylline (PTX) in SHRs in an effort to assess the impact of the rheological factor on TPR and AP. METHODS: The effects of the treatment course with PTX (100 mg/kg/day p.o. for six weeks) on BV, plasma viscosity, haematocrit, erythrocyte aggregation and deformability, mean AP (MAP), stroke volume (SV), CO, and TPR were studied in SHRs and in control Wistar Kyoto (WKY) rats. RESULTS: PTX-treated SHRs had a lower BV, lower erythrocyte aggregation, and higher erythrocyte deformability index compared with the controls. The TPR level was higher by 43{\%} compared with that in WKY rats and did not differ from the values obtained from control SHRs. In SHRs, moderate and strong positive correlations were found between BV and MAP and between BV and TPR. PTX-treated SHRs did not have any significant correlations between the above mentioned parameters. CONCLUSIONS: Treatment with PTX attenuated whole blood viscosity, but did not affect the AP and hemodynamic parameters in the experimental SHRs compared with the control SHRs. The magnitude of the rheologic effects of PTX was insufficient to cause appreciable decreases in TPR and AP.",
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T1 - Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline

AU - Plotnikov, Mark B.

AU - Aliev, Oleg I.

AU - Nosarev, Alexey V.

AU - Shamanaev, Alexander Y.

AU - Sidekhmenova, Anastasia V.

AU - Anfinogenova, Yana

AU - Anishchenko, Anna M.

AU - Pushkina, Ekaterina V.

PY - 2016/8/12

Y1 - 2016/8/12

N2 - BACKGROUND: Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. OBJECTIVE: The aim of our work was to study the haemodynamic and haemorheologic effects of a treatment course with pentoxifylline (PTX) in SHRs in an effort to assess the impact of the rheological factor on TPR and AP. METHODS: The effects of the treatment course with PTX (100 mg/kg/day p.o. for six weeks) on BV, plasma viscosity, haematocrit, erythrocyte aggregation and deformability, mean AP (MAP), stroke volume (SV), CO, and TPR were studied in SHRs and in control Wistar Kyoto (WKY) rats. RESULTS: PTX-treated SHRs had a lower BV, lower erythrocyte aggregation, and higher erythrocyte deformability index compared with the controls. The TPR level was higher by 43% compared with that in WKY rats and did not differ from the values obtained from control SHRs. In SHRs, moderate and strong positive correlations were found between BV and MAP and between BV and TPR. PTX-treated SHRs did not have any significant correlations between the above mentioned parameters. CONCLUSIONS: Treatment with PTX attenuated whole blood viscosity, but did not affect the AP and hemodynamic parameters in the experimental SHRs compared with the control SHRs. The magnitude of the rheologic effects of PTX was insufficient to cause appreciable decreases in TPR and AP.

AB - BACKGROUND: Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. OBJECTIVE: The aim of our work was to study the haemodynamic and haemorheologic effects of a treatment course with pentoxifylline (PTX) in SHRs in an effort to assess the impact of the rheological factor on TPR and AP. METHODS: The effects of the treatment course with PTX (100 mg/kg/day p.o. for six weeks) on BV, plasma viscosity, haematocrit, erythrocyte aggregation and deformability, mean AP (MAP), stroke volume (SV), CO, and TPR were studied in SHRs and in control Wistar Kyoto (WKY) rats. RESULTS: PTX-treated SHRs had a lower BV, lower erythrocyte aggregation, and higher erythrocyte deformability index compared with the controls. The TPR level was higher by 43% compared with that in WKY rats and did not differ from the values obtained from control SHRs. In SHRs, moderate and strong positive correlations were found between BV and MAP and between BV and TPR. PTX-treated SHRs did not have any significant correlations between the above mentioned parameters. CONCLUSIONS: Treatment with PTX attenuated whole blood viscosity, but did not affect the AP and hemodynamic parameters in the experimental SHRs compared with the control SHRs. The magnitude of the rheologic effects of PTX was insufficient to cause appreciable decreases in TPR and AP.

KW - Aortic ring tone

KW - Arterial blood pressure

KW - Blood viscosity

KW - Pentoxifylline

KW - SHR

KW - Total peripheral resistance

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DO - 10.3233/BIR-15100

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