Abstract
The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.
| Original language | Russian |
|---|---|
| Pages (from-to) | 452-459 |
| Number of pages | 8 |
| Journal | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk |
| Volume | 88 |
| Issue number | 4 |
| Publication status | Published - Apr 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
Cite this
Osobennosti reguliatsii gladkikh myshts sosudistoi stenki legochnoi arterii krolika. / Kapilevich, L. V.; Nosarev, A. V.; D'akova, E. I.; Kovalev, I. V.; Baskakov, M. B.; Anfinogenova, Yana Jonovna; Frolov, V. N.; Medvedev, M. A.
In: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, Vol. 88, No. 4, 04.2002, p. 452-459.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Osobennosti reguliatsii gladkikh myshts sosudistoi stenki legochnoi arterii krolika.
AU - Kapilevich, L. V.
AU - Nosarev, A. V.
AU - D'akova, E. I.
AU - Kovalev, I. V.
AU - Baskakov, M. B.
AU - Anfinogenova, Yana Jonovna
AU - Frolov, V. N.
AU - Medvedev, M. A.
PY - 2002/4
Y1 - 2002/4
N2 - The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.
AB - The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.
UR - http://www.scopus.com/inward/record.url?scp=0036548469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036548469&partnerID=8YFLogxK
M3 - Статья
C2 - 12058532
AN - SCOPUS:0036548469
VL - 88
SP - 452
EP - 459
JO - Fiziologicheskii Zhurnal Imeni I.M. Sechenova
JF - Fiziologicheskii Zhurnal Imeni I.M. Sechenova
SN - 0869-8139
IS - 4
ER -