Osobennosti reguliatsii gladkikh myshts sosudistoi stenki legochnoi arterii krolika.

Translated title of the contribution: Regulation of smooth muscles of the vascular wall in the rabbit pulmonary artery

L. V. Kapilevich, A. V. Nosarev, E. I. D'akova, I. V. Kovalev, M. B. Baskakov, Yana Jonovna Anfinogenova, V. N. Frolov, M. A. Medvedev

Research output: Contribution to journalArticle


The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.

Original languageRussian
Pages (from-to)452-459
Number of pages8
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Issue number4
Publication statusPublished - Apr 2002
Externally publishedYes


ASJC Scopus subject areas

  • Physiology

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