Osobennosti reguliatsii gladkikh myshts sosudistoi stenki legochnoi arterii krolika.

Translated title of the contribution: Regulation of smooth muscles of the vascular wall in the rabbit pulmonary artery

L. V. Kapilevich, A. V. Nosarev, E. I. D'akova, I. V. Kovalev, M. B. Baskakov, Yana Jonovna Anfinogenova, V. N. Frolov, M. A. Medvedev

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Abstract

The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.

Original language	Russian
Pages (from-to)	452-459
Number of pages	8
Journal	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume	88
Issue number	4
Publication status	Published - Apr 2002
Externally published	Yes

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Physiology

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Kapilevich, L. V., Nosarev, A. V., D'akova, E. I., Kovalev, I. V., Baskakov, M. B., Anfinogenova, Y. J., Frolov, V. N., & Medvedev, M. A. (2002). Osobennosti reguliatsii gladkikh myshts sosudistoi stenki legochnoi arterii krolika. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, 88(4), 452-459.

Osobennosti reguliatsii gladkikh myshts sosudistoi stenki legochnoi arterii krolika. / Kapilevich, L. V.; Nosarev, A. V.; D'akova, E. I.; Kovalev, I. V.; Baskakov, M. B.; Anfinogenova, Yana Jonovna; Frolov, V. N.; Medvedev, M. A.

In: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, Vol. 88, No. 4, 04.2002, p. 452-459.

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title = "Osobennosti reguliatsii gladkikh myshts sosudistoi stenki legochnoi arterii krolika.",

abstract = "The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.",

author = "Kapilevich, {L. V.} and Nosarev, {A. V.} and D'akova, {E. I.} and Kovalev, {I. V.} and Baskakov, {M. B.} and Anfinogenova, {Yana Jonovna} and Frolov, {V. N.} and Medvedev, {M. A.}",

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AU - Nosarev, A. V.

AU - D'akova, E. I.

AU - Kovalev, I. V.

AU - Baskakov, M. B.

AU - Anfinogenova, Yana Jonovna

AU - Frolov, V. N.

AU - Medvedev, M. A.

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N2 - The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.

AB - The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.

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Osobennosti reguliatsii gladkikh myshts sosudistoi stenki legochnoi arterii krolika.

Abstract

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