Reductive Amination of Ketones with Benzylamine Over Gold Supported on Different Oxides

E. Kolobova, P. Mäki-Arvela, A. Pestryakov, E. Pakrieva, L. Pascual, A. Smeds, J. Rahkila, T. Sandberg, J. Peltonen, D. Yu Murzin

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Abstract: Reductive amination of cyclohexanone with benzylamine was investigated at 100 °C under 30 bar hydrogen in toluene with five different gold catalysts prepared by deposition–precipitation method and supported on TiO2, La2O3/TiO2, CeO2/TiO2, La2O3 and CeO2. Size of metallic gold varied in the range of 2.6–3.6 nm. The best catalysts in reductive amination of cyclohexanone with benzylamine were 4 wt% Au/TiO2 and 4 wt% Au/CeO2/TiO2 giving 72% and 79% yield of the desired amine. The most acidic and basic catalysts were also unselective and exhibited low activity towards imine hydrogenation. The best catalyst 4 wt% Au/CeO2/TiO2 gave in reductive amination of propiophenone 56% selectivity to the corresponding amine at 20% conversion in 5 h. Graphical Abstract: [Figure not available: see fulltext.]

Original languageEnglish
JournalCatalysis Letters
Publication statusPublished - 1 Jan 2019



  • Cyclohexanone
  • Gold catalysts
  • Propiophenone
  • Reductive amination

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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