Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion

N. V. Naryzhnaya, L. N. Maslov, Yu B. Lishmanov, G. J. Gross

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.

Original languageEnglish
Pages (from-to)336-338
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume133
Issue number4
DOIs
Publication statusPublished - 1 Apr 2002

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Keywords

  • DADLE
  • Dalargin
  • Opioid receptors
  • Reperfusion arrhythmias

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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