Reactivity of 2,6-Dichloropurine ribonucleoside studied by 35Cl NQR spectroscopy

I. Dobak, M. Ostafin, O. Kh Poleshchuk, J. Milecki, B. Nogaj

    Research output: Contribution to journalArticle

    Abstract

    2,6-Dichloropurine ribonucleoside is a precursor in the potential synthesis of anticancer and antiviral drugs. 35Cl nuclear quadrupole resonance (NQR) studies on electronic structure and the character of C-Cl bonds may provide a valuable information about the difference in reactivity of chlorine atoms present in this compound. In this work 35Cl NQR frequencies, asymmetry parameters and double-bond character for both C-Cl bonds have been determined experimentally. These parameters were then compared with the corresponding theoretical values obtained by means of the density functional theory.

    Original languageEnglish
    Pages (from-to)47-53
    Number of pages7
    JournalApplied Magnetic Resonance
    Volume34
    Issue number1-2
    DOIs
    Publication statusPublished - Jul 2008

    Fingerprint

    nuclear quadrupole resonance
    reactivity
    spectroscopy
    chlorine
    drugs
    asymmetry
    density functional theory
    electronic structure
    synthesis
    atoms

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics

    Cite this

    Reactivity of 2,6-Dichloropurine ribonucleoside studied by 35Cl NQR spectroscopy. / Dobak, I.; Ostafin, M.; Poleshchuk, O. Kh; Milecki, J.; Nogaj, B.

    In: Applied Magnetic Resonance, Vol. 34, No. 1-2, 07.2008, p. 47-53.

    Research output: Contribution to journalArticle

    Dobak, I, Ostafin, M, Poleshchuk, OK, Milecki, J & Nogaj, B 2008, 'Reactivity of 2,6-Dichloropurine ribonucleoside studied by 35Cl NQR spectroscopy', Applied Magnetic Resonance, vol. 34, no. 1-2, pp. 47-53. https://doi.org/10.1007/s00723-008-0091-y
    Dobak, I. ; Ostafin, M. ; Poleshchuk, O. Kh ; Milecki, J. ; Nogaj, B. / Reactivity of 2,6-Dichloropurine ribonucleoside studied by 35Cl NQR spectroscopy. In: Applied Magnetic Resonance. 2008 ; Vol. 34, No. 1-2. pp. 47-53.
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