Reaction of arylpropargyl aldehydes with 2,3-bis-hydroxylamino-2,3-dimethylbutane: Synthesis of 2-(1-hydroxy-4,4,5,5-tetramethylimidazolidin-2-ylidene)-1-arylethanones

Eugene V. Tretyakov, Alexey V. Tkachev, Tatyana V. Rybalova, Yurii V. Gatilov, David W. Knight, Sergey F. Vasilevsky

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Reaction of arylpropargyl aldehydes with 2,3-dihydroxylamino-2,3-dimethylbutane results in the formation of 2-(1-hydroxy-4,4,5,5-tetramethylimidazolidin-2-ylidene)-1-arylethanones in high yields (70-80%). Allowing availability of propargyl aldehydes, this method gives new possibilities for the preparation of 2-(1-hydroxy-4,4,5,5-tetramethylimidazolidin-2-ylidene)-1-arylethanones. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)10075-10080
Number of pages6
JournalTetrahedron
Volume56
Issue number51
DOIs
Publication statusPublished - 15 Dec 2000
Externally publishedYes

Keywords

  • 1-hydroxyimidazolidin-2-ylidenes
  • Hydroxylamine derivatives
  • Propargyl aldehydes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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