Abstract
Click and go: By using click chemistry based on a new triazole forming reaction condition (see scheme), over 100 triazole compounds generated in microtiter plates from a core structure were screened for HIV protease inhibition in situ without product isolation. Potent inhibitors, active at nanomolar concentrations, against the wild type and drug resistant mutants were identified.
Original language | English |
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Pages (from-to) | 1246-1248 |
Number of pages | 3 |
Journal | ChemBioChem |
Volume | 4 |
Issue number | 11 |
DOIs | |
Publication status | Published - 7 Nov 2003 |
Externally published | Yes |
Keywords
- Click chemistry
- Enzyme
- HIV protease
- Inhibitors
- Screening
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Biochemistry, Genetics and Molecular Biology(all)