Abstract
Scintigraphic studies of fatty acid metabolism in the myocardium have been reviewed. An outline has been made to characterize principal fatty acids labeled with radioiodine, which were suggested at various times for evaluation of metabolism in the heart. The most detailed consideration has been given to experimental and clinical studies of 123I-15-(p-iodophenil) pentadecanoic acid and 123I-15-(p-iodophenil)-3-R-, methylpentadecanoic acid. Reports have been evaluated on comparing the accumulation of these radiopharmaceuticals in myocardium with data from heart perfusion scintigraphy, position emission computed tomography with 11C-palmitic acid and with 18F-fluorodeoxyglucose, biopsy and contractiveness of the left ventricle. It has been shown that myocardial scintigraphy with 123I-labelled fatty acids is instrumental not only for revealing coronary deficiency with high sensitivity and specificity but also for discriminating between viable myocardial tissue and irreversibly damaged parts of the heart.
| Original language | English |
|---|---|
| Pages (from-to) | 68-74 |
| Number of pages | 7 |
| Journal | Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost' |
| Volume | 46 |
| Issue number | 2 |
| Publication status | Published - 2001 |
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Keywords
- Coronary artery disease
- Fatty acids
- Myocardial metabolism
- Myocardial scintigraphy
ASJC Scopus subject areas
- Nuclear Energy and Engineering
Cite this
Radiopharmaceuticals on the basis of fatty acids for the evaluation of myocardial metabolism. / Lishmanov, Yu B.; Chernov, V. I.; Makarova, E. V.; Skuridin, V. S.
In: Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost', Vol. 46, No. 2, 2001, p. 68-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiopharmaceuticals on the basis of fatty acids for the evaluation of myocardial metabolism
AU - Lishmanov, Yu B.
AU - Chernov, V. I.
AU - Makarova, E. V.
AU - Skuridin, V. S.
PY - 2001
Y1 - 2001
N2 - Scintigraphic studies of fatty acid metabolism in the myocardium have been reviewed. An outline has been made to characterize principal fatty acids labeled with radioiodine, which were suggested at various times for evaluation of metabolism in the heart. The most detailed consideration has been given to experimental and clinical studies of 123I-15-(p-iodophenil) pentadecanoic acid and 123I-15-(p-iodophenil)-3-R-, methylpentadecanoic acid. Reports have been evaluated on comparing the accumulation of these radiopharmaceuticals in myocardium with data from heart perfusion scintigraphy, position emission computed tomography with 11C-palmitic acid and with 18F-fluorodeoxyglucose, biopsy and contractiveness of the left ventricle. It has been shown that myocardial scintigraphy with 123I-labelled fatty acids is instrumental not only for revealing coronary deficiency with high sensitivity and specificity but also for discriminating between viable myocardial tissue and irreversibly damaged parts of the heart.
AB - Scintigraphic studies of fatty acid metabolism in the myocardium have been reviewed. An outline has been made to characterize principal fatty acids labeled with radioiodine, which were suggested at various times for evaluation of metabolism in the heart. The most detailed consideration has been given to experimental and clinical studies of 123I-15-(p-iodophenil) pentadecanoic acid and 123I-15-(p-iodophenil)-3-R-, methylpentadecanoic acid. Reports have been evaluated on comparing the accumulation of these radiopharmaceuticals in myocardium with data from heart perfusion scintigraphy, position emission computed tomography with 11C-palmitic acid and with 18F-fluorodeoxyglucose, biopsy and contractiveness of the left ventricle. It has been shown that myocardial scintigraphy with 123I-labelled fatty acids is instrumental not only for revealing coronary deficiency with high sensitivity and specificity but also for discriminating between viable myocardial tissue and irreversibly damaged parts of the heart.
KW - Coronary artery disease
KW - Fatty acids
KW - Myocardial metabolism
KW - Myocardial scintigraphy
UR - http://www.scopus.com/inward/record.url?scp=0035763403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035763403&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0035763403
VL - 46
SP - 68
EP - 74
JO - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
JF - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
SN - 0025-8334
IS - 2
ER -