Radiopharmaceuticals on the basis of fatty acids for the evaluation of myocardial metabolism

Abstract

Scintigraphic studies of fatty acid metabolism in the myocardium have been reviewed. An outline has been made to characterize principal fatty acids labeled with radioiodine, which were suggested at various times for evaluation of metabolism in the heart. The most detailed consideration has been given to experimental and clinical studies of ¹²³I-15-(p-iodophenil) pentadecanoic acid and ¹²³I-15-(p-iodophenil)-3-R-, methylpentadecanoic acid. Reports have been evaluated on comparing the accumulation of these radiopharmaceuticals in myocardium with data from heart perfusion scintigraphy, position emission computed tomography with ¹¹C-palmitic acid and with ¹⁸F-fluorodeoxyglucose, biopsy and contractiveness of the left ventricle. It has been shown that myocardial scintigraphy with ¹²³I-labelled fatty acids is instrumental not only for revealing coronary deficiency with high sensitivity and specificity but also for discriminating between viable myocardial tissue and irreversibly damaged parts of the heart.

Original language	English
Pages (from-to)	68-74
Number of pages	7
Journal	Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
Volume	46
Issue number	2
Publication status	Published - 2001

Keywords

Coronary artery disease
Fatty acids
Myocardial metabolism
Myocardial scintigraphy

ASJC Scopus subject areas

Nuclear Energy and Engineering

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@article{8686909c789d40c09eec5a0f1e22751e,

title = "Radiopharmaceuticals on the basis of fatty acids for the evaluation of myocardial metabolism",

abstract = "Scintigraphic studies of fatty acid metabolism in the myocardium have been reviewed. An outline has been made to characterize principal fatty acids labeled with radioiodine, which were suggested at various times for evaluation of metabolism in the heart. The most detailed consideration has been given to experimental and clinical studies of 123I-15-(p-iodophenil) pentadecanoic acid and 123I-15-(p-iodophenil)-3-R-, methylpentadecanoic acid. Reports have been evaluated on comparing the accumulation of these radiopharmaceuticals in myocardium with data from heart perfusion scintigraphy, position emission computed tomography with 11C-palmitic acid and with 18F-fluorodeoxyglucose, biopsy and contractiveness of the left ventricle. It has been shown that myocardial scintigraphy with 123I-labelled fatty acids is instrumental not only for revealing coronary deficiency with high sensitivity and specificity but also for discriminating between viable myocardial tissue and irreversibly damaged parts of the heart.",

keywords = "Coronary artery disease, Fatty acids, Myocardial metabolism, Myocardial scintigraphy",

author = "Lishmanov, {Yu B.} and Chernov, {V. I.} and Makarova, {E. V.} and Skuridin, {V. S.}",

year = "2001",

language = "English",

volume = "46",

pages = "68--74",

journal = "Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'",

issn = "0025-8334",

publisher = "Izdatel'sto Radekon",

number = "2",

}

TY - JOUR

T1 - Radiopharmaceuticals on the basis of fatty acids for the evaluation of myocardial metabolism

AU - Lishmanov, Yu B.

AU - Chernov, V. I.

AU - Makarova, E. V.

AU - Skuridin, V. S.

PY - 2001

Y1 - 2001

N2 - Scintigraphic studies of fatty acid metabolism in the myocardium have been reviewed. An outline has been made to characterize principal fatty acids labeled with radioiodine, which were suggested at various times for evaluation of metabolism in the heart. The most detailed consideration has been given to experimental and clinical studies of 123I-15-(p-iodophenil) pentadecanoic acid and 123I-15-(p-iodophenil)-3-R-, methylpentadecanoic acid. Reports have been evaluated on comparing the accumulation of these radiopharmaceuticals in myocardium with data from heart perfusion scintigraphy, position emission computed tomography with 11C-palmitic acid and with 18F-fluorodeoxyglucose, biopsy and contractiveness of the left ventricle. It has been shown that myocardial scintigraphy with 123I-labelled fatty acids is instrumental not only for revealing coronary deficiency with high sensitivity and specificity but also for discriminating between viable myocardial tissue and irreversibly damaged parts of the heart.

AB - Scintigraphic studies of fatty acid metabolism in the myocardium have been reviewed. An outline has been made to characterize principal fatty acids labeled with radioiodine, which were suggested at various times for evaluation of metabolism in the heart. The most detailed consideration has been given to experimental and clinical studies of 123I-15-(p-iodophenil) pentadecanoic acid and 123I-15-(p-iodophenil)-3-R-, methylpentadecanoic acid. Reports have been evaluated on comparing the accumulation of these radiopharmaceuticals in myocardium with data from heart perfusion scintigraphy, position emission computed tomography with 11C-palmitic acid and with 18F-fluorodeoxyglucose, biopsy and contractiveness of the left ventricle. It has been shown that myocardial scintigraphy with 123I-labelled fatty acids is instrumental not only for revealing coronary deficiency with high sensitivity and specificity but also for discriminating between viable myocardial tissue and irreversibly damaged parts of the heart.

KW - Coronary artery disease

KW - Fatty acids

KW - Myocardial metabolism

KW - Myocardial scintigraphy

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AN - SCOPUS:0035763403

VL - 46

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JO - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'

JF - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'

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IS - 2

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