Radiopharmaceuticals for SPECT Cancer Detection

V. I. Chernov, A. A. Medvedeva, R. V. Zelchan, I. G. Sinilkin, E. S. Stasyuk, L. A. Larionova, E. M. Slonimskaya, E. L. Choynzonov

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1 Citation (Scopus)

Abstract

The purpose of the study was to assess the efficacy of single photon emission computed tomography (SPECT) with 199Tl and 99mTc-MIBI in the detection of breast, laryngeal and hypopharyngeal cancers. Materials and Methods: a total of 220 patients were included into the study. Of them, there were 120 patients with breast lesions (100 patients with breast cancer and 20 patients with benign breast tumors) and '00 patients with laryngeal/hypopharyngeal diseases (80 patients with laryngeal/hypopharyngeal cancer and 20 patients with benign laryngeal/hypopharyngeal lesions). Results: no abnormal 199Tl uptake was seen in all patients with benign breast and laryngeal lesions, indicating a 100% specificity of 199Tl SPECT. In breast cancer patients, increased 199Tl uptake in the breast was visualized in 94.8% patients, 99mTc-MIBI in 93.4% patients. Increased 199Tl uptake in axillary lymph nodes was detected in 60% patients and 99mTc-MIBI in 93.1% patients. In patients with laryngeal/hypopharyngeal cancer, sensitivity of SPECT with 199Tl and 99mTc-MIBI were 95%. The 199Tl SPECT sensitivity in identification of regional lymph node metastases in patients with laryngeal/hypopharyngeal cancer was 75% and the 99mTc-MIBI SPECT sensitivity was 17%. Conclusion: the data obtained show that SPECT with 199Tl and 99mTc-MIBI can be used as one of the additional imaging methods in detection of tumors.

Original languageEnglish
Article number012008
JournalIOP Conference Series: Materials Science and Engineering
Volume135
Issue number1
DOIs
Publication statusPublished - 2 Aug 2016
Event8th International Scientific Conference on Issues of Physics and Technology in Science, Industry and Medicine - Tomsk, Russian Federation
Duration: 1 Jun 20163 Jun 2016

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

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