Radiopharmaceuticals based on the glucose derivatives for tumor diagnosis

R. V. Zeltchan, A. A. Medvedeva, I. G. Sinilkin, O. V. Bragina, V. J. Chernov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The purpose of the study was to review available literature on the effcacy of radiopharmaceuticals based on glucose derivatives labeled with radioactive isotopes for detection of various cancers. material and methods. A systematic literature review was performed using the Scopus, Web of Science, MedLine, Cochrane Library, EMBASE, and Global Health databases from 2000 to 2016. Out of 900 papers in the feld of nuclear medicine, 58 were included into the review. results. 18F-fluoro-2-deoxy-D-glucose (18F-FDG) has been approved to be a powerful imaging tool for the detection of various cancers as well as for the assessment of tumor extent and therapy response. There is a continuous search for new more specifc and effective radiopharmaceuticals for visualization of tumor tissue. Many studies are devoted to the development of radiopharmaceuticals based on technetium-99m labeled glucose derivatives for tumor visualization. Russian researches have made a signifcant progress in the development of imaging agents for single-photon emission computed tomography. Conclusion. Despite the widespread use of positron emission tomography technologies, which have proved to be effective, the specialists still have a great interest in radiopharmaceuticals based on technetium-99m. The literature review suggests that the emergence of a diagnostic radiopharmaceutical based on technetium-99m labeled glucose derivative will help to improve the availability of nuclear medicine methods and their effectiveness.

Original languageEnglish
Pages (from-to)71-81
Number of pages11
JournalSiberian Journal of Oncology
Volume17
Issue number2
DOIs
Publication statusPublished - 2018

Keywords

  • Fluorodeoxyglucose
  • Glucose derivatives
  • Radionuclide diagnosis
  • Radiopharmaceuticals
  • Technetium-99m

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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