Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB 11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T

Anna Orlova, Igor Sivaev, Stefan Sjöberg, Hans Lundqvist, Vladimir Tolmachev

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The aim of this study was to investigate the use of electrophilic radioiodination in the labelling of closomonocarborane(-1). Ammonio-closo- monocarborane (ACMC, 1-NH3-1-CBH11H11) was labelled with 125I using Chloramine-T as an oxidant. Radio-TLC was used for analysis. Influence of substrate amount, oxidant concentration, and pH of the reaction media on the labelling yield was studied. A labelling yield of 80%-90% was obtained. The results of the study indicate feasibility to use derivatives of closo-monocarborane(-1) as a pendant group for indirect radioiodination of proteins, and for studying pharmacokinetics of boron-rich compounds for BNCT.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalRadiochimica Acta
Volume92
Issue number4-6
DOIs
Publication statusPublished - 2004
Externally publishedYes

Keywords

  • Ammonio-closo-monocarborane (-1)
  • Chloramine-T
  • Electrophilic radioiodination

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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