Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB 11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T

Abstract

The aim of this study was to investigate the use of electrophilic radioiodination in the labelling of closomonocarborane(-1). Ammonio-closo- monocarborane (ACMC, 1-NH₃-1-CBH_11H11) was labelled with ¹²⁵I using Chloramine-T as an oxidant. Radio-TLC was used for analysis. Influence of substrate amount, oxidant concentration, and pH of the reaction media on the labelling yield was studied. A labelling yield of 80%-90% was obtained. The results of the study indicate feasibility to use derivatives of closo-monocarborane(-1) as a pendant group for indirect radioiodination of proteins, and for studying pharmacokinetics of boron-rich compounds for BNCT.

Original language	English
Pages (from-to)	311-315
Number of pages	5
Journal	Radiochimica Acta
Volume	92
Issue number	4-6
DOIs	https://doi.org/10.1524/ract.92.4.311.35595
Publication status	Published - 2004
Externally published	Yes

Keywords

Ammonio-closo-monocarborane (-1)
Chloramine-T
Electrophilic radioiodination

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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@article{0ec8c70fd7c54db2859ba20eeef9dd99,

title = "Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB 11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T",

abstract = "The aim of this study was to investigate the use of electrophilic radioiodination in the labelling of closomonocarborane(-1). Ammonio-closo- monocarborane (ACMC, 1-NH3-1-CBH11H11) was labelled with 125I using Chloramine-T as an oxidant. Radio-TLC was used for analysis. Influence of substrate amount, oxidant concentration, and pH of the reaction media on the labelling yield was studied. A labelling yield of 80%-90% was obtained. The results of the study indicate feasibility to use derivatives of closo-monocarborane(-1) as a pendant group for indirect radioiodination of proteins, and for studying pharmacokinetics of boron-rich compounds for BNCT.",

keywords = "Ammonio-closo-monocarborane (-1), Chloramine-T, Electrophilic radioiodination",

author = "Anna Orlova and Igor Sivaev and Stefan Sj{\"o}berg and Hans Lundqvist and Vladimir Tolmachev",

note = "Funding Information: Acknowledgment. This work was financially supported by grants from the Swedish Cancer Society (Cancerfonden), the Swedish Royal Academy of Sciences, and INTAS (grant 99-00806). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2004",

doi = "10.1524/ract.92.4.311.35595",

language = "English",

volume = "92",

pages = "311--315",

journal = "Radiochimica Acta",

issn = "0033-8230",

publisher = "R. Oldenbourg",

number = "4-6",

}

TY - JOUR

T1 - Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB 11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T

AU - Orlova, Anna

AU - Sivaev, Igor

AU - Sjöberg, Stefan

AU - Lundqvist, Hans

AU - Tolmachev, Vladimir

N1 - Funding Information: Acknowledgment. This work was financially supported by grants from the Swedish Cancer Society (Cancerfonden), the Swedish Royal Academy of Sciences, and INTAS (grant 99-00806). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2004

Y1 - 2004

N2 - The aim of this study was to investigate the use of electrophilic radioiodination in the labelling of closomonocarborane(-1). Ammonio-closo- monocarborane (ACMC, 1-NH3-1-CBH11H11) was labelled with 125I using Chloramine-T as an oxidant. Radio-TLC was used for analysis. Influence of substrate amount, oxidant concentration, and pH of the reaction media on the labelling yield was studied. A labelling yield of 80%-90% was obtained. The results of the study indicate feasibility to use derivatives of closo-monocarborane(-1) as a pendant group for indirect radioiodination of proteins, and for studying pharmacokinetics of boron-rich compounds for BNCT.

AB - The aim of this study was to investigate the use of electrophilic radioiodination in the labelling of closomonocarborane(-1). Ammonio-closo- monocarborane (ACMC, 1-NH3-1-CBH11H11) was labelled with 125I using Chloramine-T as an oxidant. Radio-TLC was used for analysis. Influence of substrate amount, oxidant concentration, and pH of the reaction media on the labelling yield was studied. A labelling yield of 80%-90% was obtained. The results of the study indicate feasibility to use derivatives of closo-monocarborane(-1) as a pendant group for indirect radioiodination of proteins, and for studying pharmacokinetics of boron-rich compounds for BNCT.

KW - Ammonio-closo-monocarborane (-1)

KW - Chloramine-T

KW - Electrophilic radioiodination

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U2 - 10.1524/ract.92.4.311.35595

DO - 10.1524/ract.92.4.311.35595

M3 - Article

AN - SCOPUS:3242732999

VL - 92

SP - 311

EP - 315

JO - Radiochimica Acta

JF - Radiochimica Acta

SN - 0033-8230

IS - 4-6

ER -

Radioiodination of ammonio-closo-monocarborane, 1-H₃N-1-CB ₁₁H₁₁. Aspects of labelling chemistry in aqueous solution using Chloramine-T

Abstract

Keywords

ASJC Scopus subject areas

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