Quantitative studies of local blood flow: time course of 199Tl lipophilic chelate in organs

V. Yu Usov, V. S. Skuridin, V. I. Chernov, N. G. Krivonogov, Yu B. Lishmanov

Research output: Contribution to journalArticlepeer-review

Abstract

The authors present experimental data on accumulation of intravenously injected 199Tl diethyldithiocarbamate (DDC, 0.12 mci/kg b.w.) in the brain, heart, liver, kidneys and intestine and data on accumulation in the organs of 99mTc labeled albumin microspheres (0.15 mCi/kg b.m) injected into the left ventricles of the same rabbits. 199TI-DDC was uptaken by the organs from the blood within 60 sec after injection. Organic 199TI-DDC uptake was in good correlation with organic-fractions of cardiac output (r=0.93, p<0.02) and was constant over 2 h after injection. The uptakes of 199TI-DDC by organs were as follows (% of the injected dose): brain - 4.37±0.33%; heart - 2.73±0.24%; kidneys - 7.02±0.32%; liver - 8.95±0.61%; lungs - 6.03±0.63%; intestine - 10.92±1.63%. 199TI-DDC scintigraphy can be used as ″chemical microspheres″ for perfusion studies, providing adequate imaging of vital organs.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
JournalMeditsinskaya Radiologiya (Medical Radiology)
Volume40
Issue number1
Publication statusPublished - Jan 1995

ASJC Scopus subject areas

  • Nuclear Energy and Engineering

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