Quantitative studies of local blood flow

time course of 199Tl lipophilic chelate in organs

V. Yu Usov, V. S. Skuridin, V. I. Chernov, N. G. Krivonogov, Yu B. Lishmanov

Research output: Contribution to journalArticle

Abstract

The authors present experimental data on accumulation of intravenously injected 199Tl diethyldithiocarbamate (DDC, 0.12 mci/kg b.w.) in the brain, heart, liver, kidneys and intestine and data on accumulation in the organs of 99mTc labeled albumin microspheres (0.15 mCi/kg b.m) injected into the left ventricles of the same rabbits. 199TI-DDC was uptaken by the organs from the blood within 60 sec after injection. Organic 199TI-DDC uptake was in good correlation with organic-fractions of cardiac output (r=0.93, p<0.02) and was constant over 2 h after injection. The uptakes of 199TI-DDC by organs were as follows (% of the injected dose): brain - 4.37±0.33%; heart - 2.73±0.24%; kidneys - 7.02±0.32%; liver - 8.95±0.61%; lungs - 6.03±0.63%; intestine - 10.92±1.63%. 199TI-DDC scintigraphy can be used as ″chemical microspheres″ for perfusion studies, providing adequate imaging of vital organs.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
JournalMeditsinskaya Radiologiya (Medical Radiology)
Volume40
Issue number1
Publication statusPublished - Jan 1995

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Microspheres
Liver
Brain
Blood
Imaging techniques

ASJC Scopus subject areas

  • Nuclear Energy and Engineering

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Quantitative studies of local blood flow : time course of 199Tl lipophilic chelate in organs. / Usov, V. Yu; Skuridin, V. S.; Chernov, V. I.; Krivonogov, N. G.; Lishmanov, Yu B.

In: Meditsinskaya Radiologiya (Medical Radiology), Vol. 40, No. 1, 01.1995, p. 50-53.

Research output: Contribution to journalArticle

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