Protein synthesis in heart muscle and the cardioprotective effect of μ-opioid receptor ligands at immobilization stress

N. V. Naryznaya, L. N. Maslov, Yu B. Lishmanov

Research output: Contribution to journalArticle

Abstract

Immobilization stress leads to the increase of 99mTc-pyrophosphate accumulation in the heart that points to the cardiomyocyte damage. The stress-reaction was accompanied by a decrease of protein synthesis rate in the heart muscle and immunoreactive insulin level in blood plasma and increase of blood plasma cortisol and aldosteron. Pretreatment with agonists μ-opioid receptors DALDA and DAGO (0,1 mg/kg intraperitonealy (i.p.) twice during stress) completely prevented the stress-induction decrease of myocardial protein synthesis rate, heart damage and hormonal imbalance. Cycloheximide administration (0,3 mg/kg i.p.) increased rats myocardial membrane injury during immobilization and reduced cardioprotective effect of DALDA.

Original languageEnglish
Pages (from-to)133-134
Number of pages2
JournalVoprosy Meditsinskoj Khimii
Volume46
Issue number2
Publication statusPublished - 1 Jan 2000

Fingerprint

Opioid Receptors
Immobilization
Muscle
Myocardium
Technetium Tc 99m Pyrophosphate
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Ligands
Cycloheximide
Cardiac Myocytes
Hydrocortisone
Proteins
Blood
Heart Rate
Insulin
Plasmas
Membranes
Wounds and Injuries
Rats
tyrosyl-arginyl-phenylalanyl-lysinamide

Keywords

  • Enkephalins
  • Hormones
  • Myocardial protein synthesis
  • Stress

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Clinical Biochemistry

Cite this

Protein synthesis in heart muscle and the cardioprotective effect of μ-opioid receptor ligands at immobilization stress. / Naryznaya, N. V.; Maslov, L. N.; Lishmanov, Yu B.

In: Voprosy Meditsinskoj Khimii, Vol. 46, No. 2, 01.01.2000, p. 133-134.

Research output: Contribution to journalArticle

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