Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay

E. A. Safonova, K. A. Lopatina, A. V. Vychuzhanina, V. A. Mashanova, T. G. Razina, T. G. Borovskaya, E. P. Zueva, A. M. Gur’ev, M. V. Belousov

Research output: Contribution to journal › Article

Abstract

Using DNA comet assay we found that polysaccharides from Tussilago farfara L. reduced the intensity of polychemotherapy-induced apoptosis and DNA damage in bone marrow cells and small intestinal epithelium of C57Bl/6 mice, which attested to genoprotective properties of these polysaccharides.

Original languageEnglish
JournalBulletin of Experimental Biology and Medicine
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Tussilago
Comet Assay
Intestinal Mucosa
Combination Drug Therapy
Bone Marrow Cells
Polysaccharides
Assays
Bone
Cells
DNA
DNA Damage
Apoptosis

Keywords

  • bone marrow
  • DNA
  • polychemotherapy
  • polysaccharides
  • small intestine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay. / Safonova, E. A.; Lopatina, K. A.; Vychuzhanina, A. V.; Mashanova, V. A.; Razina, T. G.; Borovskaya, T. G.; Zueva, E. P.; Gur’ev, A. M.; Belousov, M. V.

In: Bulletin of Experimental Biology and Medicine, 01.01.2018.

Research output: Contribution to journal › Article

Safonova, EA, Lopatina, KA, Vychuzhanina, AV, Mashanova, VA, Razina, TG, Borovskaya, TG, Zueva, EP, Gur’ev, AM & Belousov, MV 2018, 'Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay', Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-018-4317-1
Safonova EA, Lopatina KA, Vychuzhanina AV, Mashanova VA, Razina TG, Borovskaya TG et al. Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay. Bulletin of Experimental Biology and Medicine. 2018 Jan 1. https://doi.org/10.1007/s10517-018-4317-1
Safonova, E. A. ; Lopatina, K. A. ; Vychuzhanina, A. V. ; Mashanova, V. A. ; Razina, T. G. ; Borovskaya, T. G. ; Zueva, E. P. ; Gur’ev, A. M. ; Belousov, M. V. / Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay. In: Bulletin of Experimental Biology and Medicine. 2018.
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AU - Vychuzhanina, A. V.

AU - Mashanova, V. A.

AU - Razina, T. G.

AU - Borovskaya, T. G.

AU - Zueva, E. P.

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AU - Belousov, M. V.

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