Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay

E. A. Safonova, K. A. Lopatina, A. V. Vychuzhanina, V. A. Mashanova, T. G. Razina, T. G. Borovskaya, E. P. Zueva, A. M. Gur’ev, M. V. Belousov

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Using DNA comet assay we found that polysaccharides from Tussilago farfara L. reduced the intensity of polychemotherapy-induced apoptosis and DNA damage in bone marrow cells and small intestinal epithelium of C57Bl/6 mice, which attested to genoprotective properties of these polysaccharides.

Original language	English
Journal	Bulletin of Experimental Biology and Medicine
DOIs	https://doi.org/10.1007/s10517-018-4317-1
Publication status	Accepted/In press - 1 Jan 2018

Fingerprint

Tussilago

Comet Assay

Intestinal Mucosa

Combination Drug Therapy

Bone Marrow Cells

Polysaccharides

Assays

Bone

Cells

DNA

DNA Damage

Apoptosis

Keywords

bone marrow
DNA
polychemotherapy
polysaccharides
small intestine

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Safonova, E. A., Lopatina, K. A., Vychuzhanina, A. V., Mashanova, V. A., Razina, T. G., Borovskaya, T. G., ... Belousov, M. V. (Accepted/In press). Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay. Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-018-4317-1

Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay. / Safonova, E. A.; Lopatina, K. A.; Vychuzhanina, A. V.; Mashanova, V. A.; Razina, T. G.; Borovskaya, T. G.; Zueva, E. P.; Gur’ev, A. M.; Belousov, M. V.

In: Bulletin of Experimental Biology and Medicine, 01.01.2018.

Research output: Contribution to journal › Article

Safonova, EA, Lopatina, KA, Vychuzhanina, AV, Mashanova, VA, Razina, TG, Borovskaya, TG, Zueva, EP, Gur’ev, AM & Belousov, MV 2018, 'Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay', Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-018-4317-1

Safonova EA, Lopatina KA, Vychuzhanina AV, Mashanova VA, Razina TG, Borovskaya TG et al. Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay. Bulletin of Experimental Biology and Medicine. 2018 Jan 1. https://doi.org/10.1007/s10517-018-4317-1

Safonova, E. A. ; Lopatina, K. A. ; Vychuzhanina, A. V. ; Mashanova, V. A. ; Razina, T. G. ; Borovskaya, T. G. ; Zueva, E. P. ; Gur’ev, A. M. ; Belousov, M. V. / Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay. In: Bulletin of Experimental Biology and Medicine. 2018.

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10.1007/s10517-018-4317-1