ПРОТЕКТОРНОЕ ДЕЙСТВИЕ КАРНОЗИНА И ОРГАНИЧЕСКИХ СОЛЕЙ ЛИТИЯ ПРИ ЭТАНОЛ-ИНДУЦИРОВАННОМ ОКИСЛИТЕЛЬНОМ ПОВРЕЖДЕНИИ БЕЛКОВ И ЛИПИДОВ ПЛАЗМЫ КРОВИ У ЗДОРОВЫХ ЛИЦ И БОЛЬНЫХ АЛКОГОЛИЗМОМ

Translated title of the contribution: Protective action of carnosine and organic lithium salts in case of ethanol-induced oxidative damage of proteins and lipids of blood plasma in healthy persons and alcoholic patients

V. D. Prokopieva, E. V. Plotnikov, E. G. Yarygina, N. A. Bokhan

Research output: Contribution to journalArticle

Abstract

Organic lithium salts containing anionic components (succinate, fumarate, pyruvate and antioxidant ascorbate) were tested for protection of blood plasma proteins and lipids against ethanol-induced oxidation in vitro. We used normothymic lithium carbonate and well-known antioxidant dipeptide carnosine (b-alanyl-L-histidine) as the reference drugs. The oxidized proteins and lipids were determined by the level of carbonylated proteins (CP) and TBA-reactive products (TBA-RP), respectively. In alcoholic patients the level of oxidized proteins and lipids was higher than in healthy persons. Incubation of blood with ethanol resulted in an increase in oxidized proteins and lipids in blood plasma of healthy persons but had no influence on the level of CP and TBA-RP in blood plasma of alcoholic patients. Lithium carbonate, lithium ascorbate, and lithium succinate exhibited protective action against ethanol-induced oxidation of biomolecules of blood plasma of healthy people. These effects were comparable with carnosine action. The studied compounds had no effect on the level of CP and TBA-RP of blood plasma of alcoholic patients.

Original languageRussian
Pages (from-to)28-32
Number of pages5
JournalBiomeditsinskaia khimiia
Volume65
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Carnosine
Alcoholics
Lithium
Blood
Ethanol
Salts
Lipids
Plasmas
Lithium Carbonate
Proteins
Blood Proteins
Antioxidants
Oxidation
Fumarates
Dipeptides
Succinic Acid
Biomolecules
Pyruvic Acid
Histidine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{e3daae8ec45d4bff8c0f1608ae73bbc5,
title = "ПРОТЕКТОРНОЕ ДЕЙСТВИЕ КАРНОЗИНА И ОРГАНИЧЕСКИХ СОЛЕЙ ЛИТИЯ ПРИ ЭТАНОЛ-ИНДУЦИРОВАННОМ ОКИСЛИТЕЛЬНОМ ПОВРЕЖДЕНИИ БЕЛКОВ И ЛИПИДОВ ПЛАЗМЫ КРОВИ У ЗДОРОВЫХ ЛИЦ И БОЛЬНЫХ АЛКОГОЛИЗМОМ",
abstract = "Organic lithium salts containing anionic components (succinate, fumarate, pyruvate and antioxidant ascorbate) were tested for protection of blood plasma proteins and lipids against ethanol-induced oxidation in vitro. We used normothymic lithium carbonate and well-known antioxidant dipeptide carnosine (b-alanyl-L-histidine) as the reference drugs. The oxidized proteins and lipids were determined by the level of carbonylated proteins (CP) and TBA-reactive products (TBA-RP), respectively. In alcoholic patients the level of oxidized proteins and lipids was higher than in healthy persons. Incubation of blood with ethanol resulted in an increase in oxidized proteins and lipids in blood plasma of healthy persons but had no influence on the level of CP and TBA-RP in blood plasma of alcoholic patients. Lithium carbonate, lithium ascorbate, and lithium succinate exhibited protective action against ethanol-induced oxidation of biomolecules of blood plasma of healthy people. These effects were comparable with carnosine action. The studied compounds had no effect on the level of CP and TBA-RP of blood plasma of alcoholic patients.",
keywords = "alcoholism, antioxidants, biomolecules of plasma, ethanol-induced oxidation, organic lithium salts",
author = "Prokopieva, {V. D.} and Plotnikov, {E. V.} and Yarygina, {E. G.} and Bokhan, {N. A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.18097/PBMC20196501028",
language = "Русский",
volume = "65",
pages = "28--32",
journal = "Biomeditsinskaya Khimiya",
issn = "2310-6905",
publisher = "Rossiiskaya Akademiya Meditsinskikh Nauk",
number = "1",

}

TY - JOUR

T1 - ПРОТЕКТОРНОЕ ДЕЙСТВИЕ КАРНОЗИНА И ОРГАНИЧЕСКИХ СОЛЕЙ ЛИТИЯ ПРИ ЭТАНОЛ-ИНДУЦИРОВАННОМ ОКИСЛИТЕЛЬНОМ ПОВРЕЖДЕНИИ БЕЛКОВ И ЛИПИДОВ ПЛАЗМЫ КРОВИ У ЗДОРОВЫХ ЛИЦ И БОЛЬНЫХ АЛКОГОЛИЗМОМ

AU - Prokopieva, V. D.

AU - Plotnikov, E. V.

AU - Yarygina, E. G.

AU - Bokhan, N. A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Organic lithium salts containing anionic components (succinate, fumarate, pyruvate and antioxidant ascorbate) were tested for protection of blood plasma proteins and lipids against ethanol-induced oxidation in vitro. We used normothymic lithium carbonate and well-known antioxidant dipeptide carnosine (b-alanyl-L-histidine) as the reference drugs. The oxidized proteins and lipids were determined by the level of carbonylated proteins (CP) and TBA-reactive products (TBA-RP), respectively. In alcoholic patients the level of oxidized proteins and lipids was higher than in healthy persons. Incubation of blood with ethanol resulted in an increase in oxidized proteins and lipids in blood plasma of healthy persons but had no influence on the level of CP and TBA-RP in blood plasma of alcoholic patients. Lithium carbonate, lithium ascorbate, and lithium succinate exhibited protective action against ethanol-induced oxidation of biomolecules of blood plasma of healthy people. These effects were comparable with carnosine action. The studied compounds had no effect on the level of CP and TBA-RP of blood plasma of alcoholic patients.

AB - Organic lithium salts containing anionic components (succinate, fumarate, pyruvate and antioxidant ascorbate) were tested for protection of blood plasma proteins and lipids against ethanol-induced oxidation in vitro. We used normothymic lithium carbonate and well-known antioxidant dipeptide carnosine (b-alanyl-L-histidine) as the reference drugs. The oxidized proteins and lipids were determined by the level of carbonylated proteins (CP) and TBA-reactive products (TBA-RP), respectively. In alcoholic patients the level of oxidized proteins and lipids was higher than in healthy persons. Incubation of blood with ethanol resulted in an increase in oxidized proteins and lipids in blood plasma of healthy persons but had no influence on the level of CP and TBA-RP in blood plasma of alcoholic patients. Lithium carbonate, lithium ascorbate, and lithium succinate exhibited protective action against ethanol-induced oxidation of biomolecules of blood plasma of healthy people. These effects were comparable with carnosine action. The studied compounds had no effect on the level of CP and TBA-RP of blood plasma of alcoholic patients.

KW - alcoholism

KW - antioxidants

KW - biomolecules of plasma

KW - ethanol-induced oxidation

KW - organic lithium salts

UR - http://www.scopus.com/inward/record.url?scp=85062386948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062386948&partnerID=8YFLogxK

U2 - 10.18097/PBMC20196501028

DO - 10.18097/PBMC20196501028

M3 - Статья

C2 - 30816094

AN - SCOPUS:85062386948

VL - 65

SP - 28

EP - 32

JO - Biomeditsinskaya Khimiya

JF - Biomeditsinskaya Khimiya

SN - 2310-6905

IS - 1

ER -