Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion

S. Yu Tsibulnikov, L. N. Maslov, A. V. Mukhomedzyanov, A. V. Krylatov, M. R. Tsibulnikova, Yu B. Lishmanov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic effect. U-50,488 injected 5 min before reperfusion 2-fold reduced the ratio of infarction to risk area. Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect. Antiarrhythmic effect of κ-opioid receptor agonists depended on activation of κ-opioid receptors.

Original languageEnglish
Pages (from-to)718-721
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume159
Issue number6
DOIs
Publication statusPublished - 1 Oct 2015

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Opioid Receptors
Reperfusion
Ischemia
Ischemic Postconditioning
Infarction
Chemical activation
ICI 199441

Keywords

  • heart
  • postconditioning
  • reperfusion
  • κ-opioid receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. / Tsibulnikov, S. Yu; Maslov, L. N.; Mukhomedzyanov, A. V.; Krylatov, A. V.; Tsibulnikova, M. R.; Lishmanov, Yu B.

In: Bulletin of Experimental Biology and Medicine, Vol. 159, No. 6, 01.10.2015, p. 718-721.

Research output: Contribution to journalArticle

Tsibulnikov, S. Yu ; Maslov, L. N. ; Mukhomedzyanov, A. V. ; Krylatov, A. V. ; Tsibulnikova, M. R. ; Lishmanov, Yu B. / Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. In: Bulletin of Experimental Biology and Medicine. 2015 ; Vol. 159, No. 6. pp. 718-721.
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