Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Leonid N. Maslov, Igor Khaliulin, Peter R. Oeltgen, Natalia V. Naryzhnaya, Jian Ming Pei, Stephen A. Brown, Yury B. Lishmanov, James M. Downey

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

It has now been demonstrated that the μ, δ1, δ2, and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.

Original languageEnglish
Pages (from-to)871-923
Number of pages53
JournalMedicinal Research Reviews
Volume36
Issue number5
DOIs
Publication statusPublished - 1 Sep 2016

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Keywords

  • cardioprotection
  • heart
  • ischemia/reperfusion injury
  • opioids
  • signal transduction

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Maslov, L. N., Khaliulin, I., Oeltgen, P. R., Naryzhnaya, N. V., Pei, J. M., Brown, S. A., Lishmanov, Y. B., & Downey, J. M. (2016). Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists. Medicinal Research Reviews, 36(5), 871-923. https://doi.org/10.1002/med.21395