Aim. To compare antianginal efficacy and tolerability of propranolol therapy in patients with stable angina pectoris and chronic hypotension (Hpts) and normotensive patients with angina of effort (Npts). Material and methods. A randomized, single-blind, placebo-controlled study was made in 35 Hpts and 33 Npts was made using bicycle exercise tests, echocardiography, stress myocardial scintigraphy with Tl-199, Results. Acute bicycle exercise tests showed high anti-ischemic activity of propranolol in 86% Hpts and 65% Npts. Stable antianginal propranolol effect in 57% Hpts was accompanied with a decrease of myocardial perfusion defect. Secondary resistance or pseudotolerance to an antianginal effect of propranolol was observed in 43% Hpts in 4-12 weeks (vs 0 of Npts; p < 0,01) as evidenced by Tl-199 stress myocardial scintigraphy. Hpts with secondary resistance and pseudotolerance to propranolol had lower control hypotension and bradicardia (p < 0,05), more anginal attacks (p < 0,001). Conclusion. Hpts had rapidly developing secondary resistance and pseudotolerance to propranolol antianginal effect, bad tolerability of the drug.
|Number of pages||5|
|Publication status||Published - 2004|
- Chronic hypotension
- Stable angina pectoris
- Stress myocardial scintigraphy
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism