TY - JOUR
T1 - Production of 76Br by a low-energy cyclotron
AU - Tolmachev, Vladimir
AU - Lövqvist, Anna
AU - Einarsson, Lars
AU - Schultz, Joachim
AU - Lundqvist, Hans
N1 - Funding Information:
This work was supported by the Swedish Medical Research Council (project No B95-14P-09822-04A) and the Medical faculty, Uppsala University.
Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 1998/12/1
Y1 - 1998/12/1
N2 - We present a production method of a positron-emitting bromine isotope 76Br (T(1/2) = 16.2 h) using a low-energy proton reaction 76Se(p, n)76Br. A pressed copper (I) selenide pellet containing enriched 76Se is used as a target. Irradiation of a 180 mg/cm2 target with 16 → 8 MeV protons gives a yield of 6570 MBq/μAh EOB. In our target set-up with a simple water cooling, the target can withstand 14 μA. Bromine-76 is separated with an efficiency of 65-75%, within 60-75 min using dry distillation at 1090°C. The loss of target material is less than 1% per separation cycle and the target can be re-used several times. Thermal chromatography is applied to separate 76Br from traces of volatilized selenium. The method allows a simple and economical production of 76Br with the use of accelerators commonly available at PET-centers.
AB - We present a production method of a positron-emitting bromine isotope 76Br (T(1/2) = 16.2 h) using a low-energy proton reaction 76Se(p, n)76Br. A pressed copper (I) selenide pellet containing enriched 76Se is used as a target. Irradiation of a 180 mg/cm2 target with 16 → 8 MeV protons gives a yield of 6570 MBq/μAh EOB. In our target set-up with a simple water cooling, the target can withstand 14 μA. Bromine-76 is separated with an efficiency of 65-75%, within 60-75 min using dry distillation at 1090°C. The loss of target material is less than 1% per separation cycle and the target can be re-used several times. Thermal chromatography is applied to separate 76Br from traces of volatilized selenium. The method allows a simple and economical production of 76Br with the use of accelerators commonly available at PET-centers.
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U2 - 10.1016/S0969-8043(97)10129-4
DO - 10.1016/S0969-8043(97)10129-4
M3 - Article
AN - SCOPUS:0031597070
VL - 49
SP - 1537
EP - 1540
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 12
ER -