Production of <sup>76</sup>Br by a low-energy cyclotron

Abstract

We present a production method of a positron-emitting bromine isotope ⁷⁶Br (T(1/2) = 16.2 h) using a low-energy proton reaction ⁷⁶Se(p, n)⁷⁶Br. A pressed copper (I) selenide pellet containing enriched ⁷⁶Se is used as a target. Irradiation of a 180 mg/cm² target with 16 → 8 MeV protons gives a yield of 6570 MBq/μAh EOB. In our target set-up with a simple water cooling, the target can withstand 14 μA. Bromine-76 is separated with an efficiency of 65-75%, within 60-75 min using dry distillation at 1090°C. The loss of target material is less than 1% per separation cycle and the target can be re-used several times. Thermal chromatography is applied to separate ⁷⁶Br from traces of volatilized selenium. The method allows a simple and economical production of ⁷⁶Br with the use of accelerators commonly available at PET-centers.

Original language	English
Pages (from-to)	1537-1540
Number of pages	4
Journal	Applied Radiation and Isotopes
Volume	49
Issue number	12
DOIs	https://doi.org/10.1016/S0969-8043(97)10129-4
Publication status	Published - 1 Dec 1998
Externally published	Yes

ASJC Scopus subject areas

Radiation

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10.1016/S0969-8043(97)10129-4

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@article{d03687d3c6af4544bf3a29af83434e7c,

title = "Production of 76Br by a low-energy cyclotron",

abstract = "We present a production method of a positron-emitting bromine isotope 76Br (T(1/2) = 16.2 h) using a low-energy proton reaction 76Se(p, n)76Br. A pressed copper (I) selenide pellet containing enriched 76Se is used as a target. Irradiation of a 180 mg/cm2 target with 16 → 8 MeV protons gives a yield of 6570 MBq/μAh EOB. In our target set-up with a simple water cooling, the target can withstand 14 μA. Bromine-76 is separated with an efficiency of 65-75%, within 60-75 min using dry distillation at 1090°C. The loss of target material is less than 1% per separation cycle and the target can be re-used several times. Thermal chromatography is applied to separate 76Br from traces of volatilized selenium. The method allows a simple and economical production of 76Br with the use of accelerators commonly available at PET-centers.",

author = "Vladimir Tolmachev and Anna L{\"o}vqvist and Lars Einarsson and Joachim Schultz and Hans Lundqvist",

note = "Funding Information: This work was supported by the Swedish Medical Research Council (project No B95-14P-09822-04A) and the Medical faculty, Uppsala University. Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.",

year = "1998",

month = dec,

day = "1",

doi = "10.1016/S0969-8043(97)10129-4",

language = "English",

volume = "49",

pages = "1537--1540",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Production of 76Br by a low-energy cyclotron

AU - Tolmachev, Vladimir

AU - Lövqvist, Anna

AU - Einarsson, Lars

AU - Schultz, Joachim

AU - Lundqvist, Hans

N1 - Funding Information: This work was supported by the Swedish Medical Research Council (project No B95-14P-09822-04A) and the Medical faculty, Uppsala University. Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.

PY - 1998/12/1

Y1 - 1998/12/1

N2 - We present a production method of a positron-emitting bromine isotope 76Br (T(1/2) = 16.2 h) using a low-energy proton reaction 76Se(p, n)76Br. A pressed copper (I) selenide pellet containing enriched 76Se is used as a target. Irradiation of a 180 mg/cm2 target with 16 → 8 MeV protons gives a yield of 6570 MBq/μAh EOB. In our target set-up with a simple water cooling, the target can withstand 14 μA. Bromine-76 is separated with an efficiency of 65-75%, within 60-75 min using dry distillation at 1090°C. The loss of target material is less than 1% per separation cycle and the target can be re-used several times. Thermal chromatography is applied to separate 76Br from traces of volatilized selenium. The method allows a simple and economical production of 76Br with the use of accelerators commonly available at PET-centers.

AB - We present a production method of a positron-emitting bromine isotope 76Br (T(1/2) = 16.2 h) using a low-energy proton reaction 76Se(p, n)76Br. A pressed copper (I) selenide pellet containing enriched 76Se is used as a target. Irradiation of a 180 mg/cm2 target with 16 → 8 MeV protons gives a yield of 6570 MBq/μAh EOB. In our target set-up with a simple water cooling, the target can withstand 14 μA. Bromine-76 is separated with an efficiency of 65-75%, within 60-75 min using dry distillation at 1090°C. The loss of target material is less than 1% per separation cycle and the target can be re-used several times. Thermal chromatography is applied to separate 76Br from traces of volatilized selenium. The method allows a simple and economical production of 76Br with the use of accelerators commonly available at PET-centers.

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U2 - 10.1016/S0969-8043(97)10129-4

DO - 10.1016/S0969-8043(97)10129-4

M3 - Article

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VL - 49

SP - 1537

EP - 1540

JO - Applied Radiation and Isotopes

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