Production of novel ceramic porous surfaces tailored for bone tissue engineering

Abstract

Moderate toughness and poor biological features of ceramics may hinder their application as modern bio-active implants. The paper presents a new, cost-effective, environmentally friendly and simple production method of open-cell calcium phosphate (CP) ceramic foams, by employing powders' compaction, dissolution and sintering, aiming at producing highly bio-active 3D surface scaffolds. The process parameters were properly adjusted to optimize the quality and structure of CP foams, and samples with various porosity (60-75 vol%) and pore size (0.28-0.50 mm) were fabricated, characterized and mechanically tested. Cell viability, adhesion and proliferation investigations revealed an excellent potential for application in bone tissue engineering.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	CIRP Annals - Manufacturing Technology
Volume	63
Issue number	1
DOIs	https://doi.org/10.1016/j.cirp.2014.03.044
Publication status	Published - 2014
Externally published	Yes

Keywords

Biomedical surfaces
Cell growth
Powder sintering

ASJC Scopus subject areas

Mechanical Engineering
Industrial and Manufacturing Engineering

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10.1016/j.cirp.2014.03.044

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title = "Production of novel ceramic porous surfaces tailored for bone tissue engineering",

abstract = "Moderate toughness and poor biological features of ceramics may hinder their application as modern bio-active implants. The paper presents a new, cost-effective, environmentally friendly and simple production method of open-cell calcium phosphate (CP) ceramic foams, by employing powders' compaction, dissolution and sintering, aiming at producing highly bio-active 3D surface scaffolds. The process parameters were properly adjusted to optimize the quality and structure of CP foams, and samples with various porosity (60-75 vol%) and pore size (0.28-0.50 mm) were fabricated, characterized and mechanically tested. Cell viability, adhesion and proliferation investigations revealed an excellent potential for application in bone tissue engineering.",

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author = "Nikolaos Michailidis and Fani Stergioudi and Konstantina Viglaki and Maria Chatzinikolaidou",

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AU - Michailidis, Nikolaos

AU - Stergioudi, Fani

AU - Viglaki, Konstantina

AU - Chatzinikolaidou, Maria

PY - 2014

Y1 - 2014

N2 - Moderate toughness and poor biological features of ceramics may hinder their application as modern bio-active implants. The paper presents a new, cost-effective, environmentally friendly and simple production method of open-cell calcium phosphate (CP) ceramic foams, by employing powders' compaction, dissolution and sintering, aiming at producing highly bio-active 3D surface scaffolds. The process parameters were properly adjusted to optimize the quality and structure of CP foams, and samples with various porosity (60-75 vol%) and pore size (0.28-0.50 mm) were fabricated, characterized and mechanically tested. Cell viability, adhesion and proliferation investigations revealed an excellent potential for application in bone tissue engineering.

AB - Moderate toughness and poor biological features of ceramics may hinder their application as modern bio-active implants. The paper presents a new, cost-effective, environmentally friendly and simple production method of open-cell calcium phosphate (CP) ceramic foams, by employing powders' compaction, dissolution and sintering, aiming at producing highly bio-active 3D surface scaffolds. The process parameters were properly adjusted to optimize the quality and structure of CP foams, and samples with various porosity (60-75 vol%) and pore size (0.28-0.50 mm) were fabricated, characterized and mechanically tested. Cell viability, adhesion and proliferation investigations revealed an excellent potential for application in bone tissue engineering.

KW - Biomedical surfaces

KW - Cell growth

KW - Powder sintering

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