Prevention of experimental epinephrine-induced arrhythmias with agonists of δ1-and δ2-opiate receptors

Abstract

Agonists of δ₁- and δ₂-opiate receptors prevent epinephrine-induced arrhythmias in rats after intracerebroventricular administration. The antagonist of δ-opiate receptors ICI 174,864 blocks antiarrhythmic effect of the selective agonist of δ-opiate receptors DTLET and exhibits no antiarrhythmic activity by itself. It is shown that antiarrhythmic effect of DTLET is associated with increased vagal tone.

Original language	English
Pages (from-to)	873-875
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	124
Issue number	9
Publication status	Published - Sep 1997

Keywords

δ- and δ-opiate receptors
Arrhythmia

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Agonists of δ1- and δ2-opiate receptors prevent epinephrine-induced arrhythmias in rats after intracerebroventricular administration. The antagonist of δ-opiate receptors ICI 174,864 blocks antiarrhythmic effect of the selective agonist of δ-opiate receptors DTLET and exhibits no antiarrhythmic activity by itself. It is shown that antiarrhythmic effect of DTLET is associated with increased vagal tone.",

keywords = "δ- and δ-opiate receptors, Arrhythmia",

author = "Lishmanov, {Yu B.} and Ugdyzhekova, {D. S.} and Maslov, {L. N.}",

year = "1997",

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AU - Lishmanov, Yu B.

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AU - Maslov, L. N.

PY - 1997/9

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N2 - Agonists of δ1- and δ2-opiate receptors prevent epinephrine-induced arrhythmias in rats after intracerebroventricular administration. The antagonist of δ-opiate receptors ICI 174,864 blocks antiarrhythmic effect of the selective agonist of δ-opiate receptors DTLET and exhibits no antiarrhythmic activity by itself. It is shown that antiarrhythmic effect of DTLET is associated with increased vagal tone.

AB - Agonists of δ1- and δ2-opiate receptors prevent epinephrine-induced arrhythmias in rats after intracerebroventricular administration. The antagonist of δ-opiate receptors ICI 174,864 blocks antiarrhythmic effect of the selective agonist of δ-opiate receptors DTLET and exhibits no antiarrhythmic activity by itself. It is shown that antiarrhythmic effect of DTLET is associated with increased vagal tone.

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Prevention of experimental epinephrine-induced arrhythmias with agonists of δ₁-and δ₂-opiate receptors

Abstract

Keywords

ASJC Scopus subject areas

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