Prevention of experimental epinephrine-induced arrhythmias with agonists of δ1-and δ2-opiate receptors

Yu B. Lishmanov, D. S. Ugdyzhekova, L. N. Maslov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Agonists of δ1- and δ2-opiate receptors prevent epinephrine-induced arrhythmias in rats after intracerebroventricular administration. The antagonist of δ-opiate receptors ICI 174,864 blocks antiarrhythmic effect of the selective agonist of δ-opiate receptors DTLET and exhibits no antiarrhythmic activity by itself. It is shown that antiarrhythmic effect of DTLET is associated with increased vagal tone.

Original languageEnglish
Pages (from-to)873-875
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume124
Issue number9
Publication statusPublished - Sep 1997

Keywords

  • δ- and δ-opiate receptors
  • Arrhythmia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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