Preparation of [76Br] 5-bromo-2-thiouracil, a positron-emitting melanoma localizing agent

V. Tolmachev, A. Orlova, A. Sundin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Derivatives of 2-thiouracil are known to incorporate into the growing melanin pigment of melanomas as false melanin precursors. Animal and pilot patient studies have demonstrated, that radioiodinated 5-iodo-2-thiouracil is a promising agent for visualization of melanotic melanomas. In this study, 2-bromo-2-thiouracil was labeled using the positron-emitting isotope 76Br (T1/2 = 16.2 h), which potentially enables to use such advantages of PET as superior spatial resolution and possibility to quantify radioactivity concentration in vivo. The use of Chloramine-T as oxidant provided a labeling efficiency of about 70%.

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume251
Issue number3
DOIs
Publication statusPublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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