@inbook{085af8a1411e45cca1d300db648231f6,
title = "Preparation of Conjugates for Affibody-Based PNA-Mediated Pretargeting",
abstract = "Affibody molecules are small engineered scaffold proteins suitable for in vivo tumor targeting. Radionuclide molecular imaging using directly radiolabelled affibody molecules provides excellent imaging. However, affibody molecules have a high renal reabsorption, which complicates their use for radionuclide therapy. The high renal reabsorption is a common problem for the use of engineered scaffold proteins for radionuclide therapy. Affibody-based PNA-mediated pretargeting reduces dramatically the absorbed dose to the kidneys and makes affibody-based radionuclide therapy possible. This methodology might, hopefully, solve the problem of high renal reabsorption for radionuclide therapy mediated by other engineered scaffold proteins.",
keywords = "In, Lu, Co, Ga, Affibody molecules, Peptide synthesis, PNA, Pretargeting, Scaffold protein, Sortase A",
author = "Mohamed Altai and Anzhelika Vorobyeva and Vladimir Tolmachev and Karlstr{\"o}m, {Amelie Eriksson} and Kristina Westerlund",
note = "Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.1007/978-1-0716-0243-0_18",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "283--304",
booktitle = "Methods in Molecular Biology",
}