Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity

Abstract

Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.

Original language	English
Title of host publication	Multifunctional Materials
Subtitle of host publication	Development and Application
Publisher	Trans Tech Publications Ltd
Pages	475-480
Number of pages	6
ISBN (Print)	9783038357292
DOIs	https://doi.org/10.4028/www.scientific.net/KEM.683.475
Publication status	Published - 1 Jan 2016
Event	12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015 - Tomsk, Russian Federation Duration: 21 Apr 2015 → 24 Apr 2015

Publication series

Name	Key Engineering Materials
Volume	683
ISSN (Print)	1013-9826

Conference

Conference	12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015
Country	Russian Federation
City	Tomsk
Period	21.4.15 → 24.4.15

Keywords

Biocompatibility
Biocomposite material
Calciumphosphate layer
Cytokines
Hydroxyapatite
Macrophages
Monocytes
Polylactic acid

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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Shapovalova, Y., Lytkina, D., Rasskazova, L., Zhuk, I., Gudima, A., Filimoshkin, A., Korotchenko, N., Kurzina, I., & Kzhyshkowska, J. (2016). Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. In Multifunctional Materials: Development and Application (pp. 475-480). (Key Engineering Materials; Vol. 683). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.683.475

Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. / Shapovalova, Yelena; Lytkina, Daria; Rasskazova, Liudmila; Zhuk, Ilya; Gudima, Alexandru; Filimoshkin, Anatoly; Korotchenko, Natalya; Kurzina, Irina; Kzhyshkowska, Julia.

Multifunctional Materials: Development and Application. Trans Tech Publications Ltd, 2016. p. 475-480 (Key Engineering Materials; Vol. 683).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Shapovalova, Y, Lytkina, D, Rasskazova, L, Zhuk, I, Gudima, A, Filimoshkin, A, Korotchenko, N, Kurzina, I & Kzhyshkowska, J 2016, Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. in Multifunctional Materials: Development and Application. Key Engineering Materials, vol. 683, Trans Tech Publications Ltd, pp. 475-480, 12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015, Tomsk, Russian Federation, 21.4.15. https://doi.org/10.4028/www.scientific.net/KEM.683.475

Shapovalova Y, Lytkina D, Rasskazova L, Zhuk I, Gudima A, Filimoshkin A et al. Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. In Multifunctional Materials: Development and Application. Trans Tech Publications Ltd. 2016. p. 475-480. (Key Engineering Materials). https://doi.org/10.4028/www.scientific.net/KEM.683.475

Shapovalova, Yelena ; Lytkina, Daria ; Rasskazova, Liudmila ; Zhuk, Ilya ; Gudima, Alexandru ; Filimoshkin, Anatoly ; Korotchenko, Natalya ; Kurzina, Irina ; Kzhyshkowska, Julia. / Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. Multifunctional Materials: Development and Application. Trans Tech Publications Ltd, 2016. pp. 475-480 (Key Engineering Materials).

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abstract = "Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.",

keywords = "Biocompatibility, Biocomposite material, Calciumphosphate layer, Cytokines, Hydroxyapatite, Macrophages, Monocytes, Polylactic acid",

author = "Yelena Shapovalova and Daria Lytkina and Liudmila Rasskazova and Ilya Zhuk and Alexandru Gudima and Anatoly Filimoshkin and Natalya Korotchenko and Irina Kurzina and Julia Kzhyshkowska",

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AU - Zhuk, Ilya

AU - Gudima, Alexandru

AU - Filimoshkin, Anatoly

AU - Korotchenko, Natalya

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