Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity

Yelena Shapovalova, Daria Lytkina, Liudmila Rasskazova, Ilya Zhuk, Alexandru Gudima, Anatoly Filimoshkin, Natalya Korotchenko, Irina Kurzina, Julia Kzhyshkowska

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Citations (Scopus)

Abstract

Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.

Original language	English
Title of host publication	Multifunctional Materials
Subtitle of host publication	Development and Application
Publisher	Trans Tech Publications Ltd
Pages	475-480
Number of pages	6
ISBN (Print)	9783038357292
DOIs	https://doi.org/10.4028/www.scientific.net/KEM.683.475
Publication status	Published - 1 Jan 2016
Event	12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015 - Tomsk, Russian Federation Duration: 21 Apr 2015 → 24 Apr 2015

Publication series

Name	Key Engineering Materials
Volume	683
ISSN (Print)	1013-9826

Conference

Conference	12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015
Country	Russian Federation
City	Tomsk
Period	21.4.15 → 24.4.15

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Keywords

Biocompatibility
Biocomposite material
Calciumphosphate layer
Cytokines
Hydroxyapatite
Macrophages
Monocytes
Polylactic acid

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

Shapovalova, Y., Lytkina, D., Rasskazova, L., Zhuk, I., Gudima, A., Filimoshkin, A., Korotchenko, N., Kurzina, I., & Kzhyshkowska, J. (2016). Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. In Multifunctional Materials: Development and Application (pp. 475-480). (Key Engineering Materials; Vol. 683). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.683.475

Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. / Shapovalova, Yelena; Lytkina, Daria; Rasskazova, Liudmila; Zhuk, Ilya; Gudima, Alexandru; Filimoshkin, Anatoly; Korotchenko, Natalya; Kurzina, Irina; Kzhyshkowska, Julia.

Multifunctional Materials: Development and Application. Trans Tech Publications Ltd, 2016. p. 475-480 (Key Engineering Materials; Vol. 683).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Shapovalova, Y, Lytkina, D, Rasskazova, L, Zhuk, I, Gudima, A, Filimoshkin, A, Korotchenko, N, Kurzina, I & Kzhyshkowska, J 2016, Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. in Multifunctional Materials: Development and Application. Key Engineering Materials, vol. 683, Trans Tech Publications Ltd, pp. 475-480, 12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015, Tomsk, Russian Federation, 21.4.15. https://doi.org/10.4028/www.scientific.net/KEM.683.475

Shapovalova Y, Lytkina D, Rasskazova L, Zhuk I, Gudima A, Filimoshkin A et al. Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. In Multifunctional Materials: Development and Application. Trans Tech Publications Ltd. 2016. p. 475-480. (Key Engineering Materials). https://doi.org/10.4028/www.scientific.net/KEM.683.475

Shapovalova, Yelena ; Lytkina, Daria ; Rasskazova, Liudmila ; Zhuk, Ilya ; Gudima, Alexandru ; Filimoshkin, Anatoly ; Korotchenko, Natalya ; Kurzina, Irina ; Kzhyshkowska, Julia. / Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. Multifunctional Materials: Development and Application. Trans Tech Publications Ltd, 2016. pp. 475-480 (Key Engineering Materials).

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Access to Document

10.4028/www.scientific.net/KEM.683.475