Abstract
Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.
| Original language | English |
|---|---|
| Title of host publication | Multifunctional Materials |
| Subtitle of host publication | Development and Application |
| Publisher | Trans Tech Publications Ltd |
| Pages | 475-480 |
| Number of pages | 6 |
| ISBN (Print) | 9783038357292 |
| DOIs | |
| Publication status | Published - 1 Jan 2016 |
| Event | 12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015 - Tomsk, Russian Federation Duration: 21 Apr 2015 → 24 Apr 2015 |
Publication series
| Name | Key Engineering Materials |
|---|---|
| Volume | 683 |
| ISSN (Print) | 1013-9826 |
Conference
| Conference | 12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015 |
|---|---|
| Country | Russian Federation |
| City | Tomsk |
| Period | 21.4.15 → 24.4.15 |
Fingerprint
Keywords
- Biocompatibility
- Biocomposite material
- Calciumphosphate layer
- Cytokines
- Hydroxyapatite
- Macrophages
- Monocytes
- Polylactic acid
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Cite this
Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. / Shapovalova, Yelena; Lytkina, Daria; Rasskazova, Liudmila; Zhuk, Ilya; Gudima, Alexandru; Filimoshkin, Anatoly; Korotchenko, Natalya; Kurzina, Irina; Kzhyshkowska, Julia.
Multifunctional Materials: Development and Application. Trans Tech Publications Ltd, 2016. p. 475-480 (Key Engineering Materials; Vol. 683).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity
AU - Shapovalova, Yelena
AU - Lytkina, Daria
AU - Rasskazova, Liudmila
AU - Zhuk, Ilya
AU - Gudima, Alexandru
AU - Filimoshkin, Anatoly
AU - Korotchenko, Natalya
AU - Kurzina, Irina
AU - Kzhyshkowska, Julia
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.
AB - Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.
KW - Biocompatibility
KW - Biocomposite material
KW - Calciumphosphate layer
KW - Cytokines
KW - Hydroxyapatite
KW - Macrophages
KW - Monocytes
KW - Polylactic acid
UR - http://www.scopus.com/inward/record.url?scp=84959076278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959076278&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.683.475
DO - 10.4028/www.scientific.net/KEM.683.475
M3 - Conference contribution
AN - SCOPUS:84959076278
SN - 9783038357292
T3 - Key Engineering Materials
SP - 475
EP - 480
BT - Multifunctional Materials
PB - Trans Tech Publications Ltd
ER -