Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity

Yelena Shapovalova, Daria Lytkina, Liudmila Rasskazova, Ilya Zhuk, Alexandru Gudima, Anatoly Filimoshkin, Natalya Korotchenko, Irina Kurzina, Julia Kzhyshkowska

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    7 Citations (Scopus)

    Abstract

    Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.

    Original languageEnglish
    Title of host publicationMultifunctional Materials
    Subtitle of host publicationDevelopment and Application
    PublisherTrans Tech Publications Ltd
    Pages475-480
    Number of pages6
    ISBN (Print)9783038357292
    DOIs
    Publication statusPublished - 1 Jan 2016
    Event12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015 - Tomsk, Russian Federation
    Duration: 21 Apr 201524 Apr 2015

    Publication series

    NameKey Engineering Materials
    Volume683
    ISSN (Print)1013-9826

    Conference

    Conference12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015
    CountryRussian Federation
    CityTomsk
    Period21.4.1524.4.15

    Keywords

    • Biocompatibility
    • Biocomposite material
    • Calciumphosphate layer
    • Cytokines
    • Hydroxyapatite
    • Macrophages
    • Monocytes
    • Polylactic acid

    ASJC Scopus subject areas

    • Materials Science(all)
    • Mechanics of Materials
    • Mechanical Engineering

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  • Cite this

    Shapovalova, Y., Lytkina, D., Rasskazova, L., Zhuk, I., Gudima, A., Filimoshkin, A., Korotchenko, N., Kurzina, I., & Kzhyshkowska, J. (2016). Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. In Multifunctional Materials: Development and Application (pp. 475-480). (Key Engineering Materials; Vol. 683). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.683.475