TY - GEN
T1 - Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity
AU - Shapovalova, Yelena
AU - Lytkina, Daria
AU - Rasskazova, Liudmila
AU - Zhuk, Ilya
AU - Gudima, Alexandru
AU - Filimoshkin, Anatoly
AU - Korotchenko, Natalya
AU - Kurzina, Irina
AU - Kzhyshkowska, Julia
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.
AB - Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.
KW - Biocompatibility
KW - Biocomposite material
KW - Calciumphosphate layer
KW - Cytokines
KW - Hydroxyapatite
KW - Macrophages
KW - Monocytes
KW - Polylactic acid
UR - http://www.scopus.com/inward/record.url?scp=84959076278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959076278&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.683.475
DO - 10.4028/www.scientific.net/KEM.683.475
M3 - Conference contribution
AN - SCOPUS:84959076278
SN - 9783038357292
T3 - Key Engineering Materials
SP - 475
EP - 480
BT - Multifunctional Materials
PB - Trans Tech Publications Ltd
T2 - 12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015
Y2 - 21 April 2015 through 24 April 2015
ER -