Preparation of a silicate-containing hydroxyapatite-based coating by magnetron sputtering: structure and osteoblast-like MG63 cells in vitro study

Structure and osteoblast-like MG63 cells in vitro study

M. A. Surmeneva, A. Kovtun, A. Peetsch, S. N. Goroja, A. A. Sharonova, V. F. Pichugin, I. Y. Grubova, A. A. Ivanova, A. D. Teresov, Nikolay Nikolaevich Koval, V. Buck, A. Wittmar, M. Ulbricht, O. Prymak, M. Epple, R. A. Surmenev

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Abstract

Silicate-containing hydroxyapatite-based coatings with different structure and calcium/phosphate ratios were prepared by radio-frequency magnetron sputtering on silicon and titanium substrates, respectively. Scanning electron microscopy, X-ray diffraction and IR spectroscopy were used to investigate the effect of the substrate bias on the properties of the silicate-containing hydroxyapatite-based coatings. The deposition rate, composition, and microstructure of the deposited coatings were all controlled by changing the bias voltage from grounded (0 V) to -50 and -100 V. The biocompatibility was assessed by cell culture with human osteoblast-like cells (MG-63 cell line), showing a good biocompatibility and cell growth on the substrates.

Original languageEnglish
Pages (from-to)11240-11246
Number of pages7
JournalRSC Advances
Volume3
Issue number28
DOIs
Publication statusPublished - 28 Jul 2013

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Silicates
Osteoblasts
Durapatite
Hydroxyapatite
Magnetron sputtering
Biocompatibility
Coatings
Substrates
Calcium phosphate
Cell growth
Silicon
Bias voltage
Titanium
Deposition rates
Cell culture
Infrared spectroscopy
Cells
X ray diffraction
Microstructure
Scanning electron microscopy

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

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title = "Preparation of a silicate-containing hydroxyapatite-based coating by magnetron sputtering: structure and osteoblast-like MG63 cells in vitro study: Structure and osteoblast-like MG63 cells in vitro study",
abstract = "Silicate-containing hydroxyapatite-based coatings with different structure and calcium/phosphate ratios were prepared by radio-frequency magnetron sputtering on silicon and titanium substrates, respectively. Scanning electron microscopy, X-ray diffraction and IR spectroscopy were used to investigate the effect of the substrate bias on the properties of the silicate-containing hydroxyapatite-based coatings. The deposition rate, composition, and microstructure of the deposited coatings were all controlled by changing the bias voltage from grounded (0 V) to -50 and -100 V. The biocompatibility was assessed by cell culture with human osteoblast-like cells (MG-63 cell line), showing a good biocompatibility and cell growth on the substrates.",
author = "Surmeneva, {M. A.} and A. Kovtun and A. Peetsch and Goroja, {S. N.} and Sharonova, {A. A.} and Pichugin, {V. F.} and Grubova, {I. Y.} and Ivanova, {A. A.} and Teresov, {A. D.} and Koval, {Nikolay Nikolaevich} and V. Buck and A. Wittmar and M. Ulbricht and O. Prymak and M. Epple and Surmenev, {R. A.}",
year = "2013",
month = "7",
day = "28",
doi = "10.1039/c3ra40446c",
language = "English",
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pages = "11240--11246",
journal = "RSC Advances",
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TY - JOUR

T1 - Preparation of a silicate-containing hydroxyapatite-based coating by magnetron sputtering: structure and osteoblast-like MG63 cells in vitro study

T2 - Structure and osteoblast-like MG63 cells in vitro study

AU - Surmeneva, M. A.

AU - Kovtun, A.

AU - Peetsch, A.

AU - Goroja, S. N.

AU - Sharonova, A. A.

AU - Pichugin, V. F.

AU - Grubova, I. Y.

AU - Ivanova, A. A.

AU - Teresov, A. D.

AU - Koval, Nikolay Nikolaevich

AU - Buck, V.

AU - Wittmar, A.

AU - Ulbricht, M.

AU - Prymak, O.

AU - Epple, M.

AU - Surmenev, R. A.

PY - 2013/7/28

Y1 - 2013/7/28

N2 - Silicate-containing hydroxyapatite-based coatings with different structure and calcium/phosphate ratios were prepared by radio-frequency magnetron sputtering on silicon and titanium substrates, respectively. Scanning electron microscopy, X-ray diffraction and IR spectroscopy were used to investigate the effect of the substrate bias on the properties of the silicate-containing hydroxyapatite-based coatings. The deposition rate, composition, and microstructure of the deposited coatings were all controlled by changing the bias voltage from grounded (0 V) to -50 and -100 V. The biocompatibility was assessed by cell culture with human osteoblast-like cells (MG-63 cell line), showing a good biocompatibility and cell growth on the substrates.

AB - Silicate-containing hydroxyapatite-based coatings with different structure and calcium/phosphate ratios were prepared by radio-frequency magnetron sputtering on silicon and titanium substrates, respectively. Scanning electron microscopy, X-ray diffraction and IR spectroscopy were used to investigate the effect of the substrate bias on the properties of the silicate-containing hydroxyapatite-based coatings. The deposition rate, composition, and microstructure of the deposited coatings were all controlled by changing the bias voltage from grounded (0 V) to -50 and -100 V. The biocompatibility was assessed by cell culture with human osteoblast-like cells (MG-63 cell line), showing a good biocompatibility and cell growth on the substrates.

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