Preclinical toxicological evaluation of pentamang and mangascan

A. A. Churin, G. V. Karpova, T. I. Fomina, T. V. Vetoshkina, T. Yu Dubskaya, O. L. Voronova, V. D. Filimonov, M. L. Belyanin, V. Yu Usov

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We have carried out a preclinical toxicological investigation (acute toxicity evaluation) of Mangascan (0.5 M solution of manganese(II) - EDTA complex) and Pentamang (0.5 M solution of manganese(II) - DTPA complex), a new paramagnetic contrast agents for MRI procedures. In 14 days after single intravenous introduction of Mangascan (10.0 ml/kg) or Pentamang (5.0 ml/kg) to rats, no any toxic influence of the studied agents was detected in the general condition, bone marrow, cardiovascular and central nervous systems, and liver and kidney functions of experimental animals. No pathological changes were observed in the functional activity and morphology of the internal organs and systems. The results showed that both Mangascan and Pentamang belong to the class of low toxicity substances.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Issue number4
Publication statusPublished - 2008


ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Churin, A. A., Karpova, G. V., Fomina, T. I., Vetoshkina, T. V., Dubskaya, T. Y., Voronova, O. L., ... Usov, V. Y. (2008). Preclinical toxicological evaluation of pentamang and mangascan. Eksperimental'naya i Klinicheskaya Farmakologiya, 71(4), 49-52.