Preclinical toxicological evaluation of pentamang and mangascan

A. A. Churin, G. V. Karpova, T. I. Fomina, T. V. Vetoshkina, T. Yu Dubskaya, O. L. Voronova, V. D. Filimonov, M. L. Belyanin, V. Yu Usov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have carried out a preclinical toxicological investigation (acute toxicity evaluation) of Mangascan (0.5 M solution of manganese(II) - EDTA complex) and Pentamang (0.5 M solution of manganese(II) - DTPA complex), a new paramagnetic contrast agents for MRI procedures. In 14 days after single intravenous introduction of Mangascan (10.0 ml/kg) or Pentamang (5.0 ml/kg) to rats, no any toxic influence of the studied agents was detected in the general condition, bone marrow, cardiovascular and central nervous systems, and liver and kidney functions of experimental animals. No pathological changes were observed in the functional activity and morphology of the internal organs and systems. The results showed that both Mangascan and Pentamang belong to the class of low toxicity substances.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume71
Issue number4
Publication statusPublished - 2008

Fingerprint

Manganese
Toxicology
Toxicity
Pentetic Acid
Poisons
Neurology
Edetic Acid
Liver
Magnetic resonance imaging
Contrast Media
Rats
Bone
Animals
Central Nervous System
Bone Marrow
Kidney

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Churin, A. A., Karpova, G. V., Fomina, T. I., Vetoshkina, T. V., Dubskaya, T. Y., Voronova, O. L., ... Usov, V. Y. (2008). Preclinical toxicological evaluation of pentamang and mangascan. Eksperimental'naya i Klinicheskaya Farmakologiya, 71(4), 49-52.

Preclinical toxicological evaluation of pentamang and mangascan. / Churin, A. A.; Karpova, G. V.; Fomina, T. I.; Vetoshkina, T. V.; Dubskaya, T. Yu; Voronova, O. L.; Filimonov, V. D.; Belyanin, M. L.; Usov, V. Yu.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 71, No. 4, 2008, p. 49-52.

Research output: Contribution to journalArticle

Churin, AA, Karpova, GV, Fomina, TI, Vetoshkina, TV, Dubskaya, TY, Voronova, OL, Filimonov, VD, Belyanin, ML & Usov, VY 2008, 'Preclinical toxicological evaluation of pentamang and mangascan', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 71, no. 4, pp. 49-52.
Churin AA, Karpova GV, Fomina TI, Vetoshkina TV, Dubskaya TY, Voronova OL et al. Preclinical toxicological evaluation of pentamang and mangascan. Eksperimental'naya i Klinicheskaya Farmakologiya. 2008;71(4):49-52.
Churin, A. A. ; Karpova, G. V. ; Fomina, T. I. ; Vetoshkina, T. V. ; Dubskaya, T. Yu ; Voronova, O. L. ; Filimonov, V. D. ; Belyanin, M. L. ; Usov, V. Yu. / Preclinical toxicological evaluation of pentamang and mangascan. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2008 ; Vol. 71, No. 4. pp. 49-52.
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