Preclinical investigation of the safety of eplir

A. S. Saratikov, N. S. Livshits, F. I. Burchenkova, N. G. Kadychagova, T. P. Novozheeva, R. R. Akhmedzhanov, T. V. Perevozchikova, L. V. Bashirova

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Abstract

The preclinical toxicological evaluation of eplir, a new hepatoprotective drug, has been performed. It was established that, in terms of the acute toxicity parameters, eplir is a low-toxicity substance. A six-month peroral administration of the drug in a dose of 30, 150, and 300 mg/kg in rats and 100 mg/kg in dogs did not cause any substantial functional and structural disorders in the organs and systems of the experimental animals. Eplir does not possess mutagenic, carcinogenic, allergenic, and immunotoxic properties and does not affect the reproductive function.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalPharmaceutical Chemistry Journal
Volume39
Issue number2
DOIs
Publication statusPublished - 1 Feb 2005

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Saratikov, A. S., Livshits, N. S., Burchenkova, F. I., Kadychagova, N. G., Novozheeva, T. P., Akhmedzhanov, R. R., Perevozchikova, T. V., & Bashirova, L. V. (2005). Preclinical investigation of the safety of eplir. Pharmaceutical Chemistry Journal, 39(2), 64-66. https://doi.org/10.1007/s11094-005-0082-3