Abstract
The acute and chronic toxicity of a new preparation of a(1,2)-L-rhamno-a(1,4)-D-galactopyranozyluronane from Acorus calamus L. intended for antitumor therapy was studied at the stage of preclinical research. As a result of acute experiments, it was established that the drug administration in the maximum permissible amount had no toxic effects on test animals (rats and mice). The study of chronic toxicity showed that the new drug intraperitoneally administered in doses of 20,100 and 200 mg/kg for three months did not cause death of animals or any pathological changes of their general condition, body weight dynamics, and functional activity of internal organs and systems. Clinical and laboratory parameters in animals during chronic experiments did not differ from those in healthy animals. Some dose-dependent local irritation was observed.
| Original language | English |
|---|---|
| Pages (from-to) | 21-24 |
| Number of pages | 4 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 82 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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Keywords
- Acorus calamus L
- Acute toxicity
- Chronic toxicity
- Mice
- Polysaccharides
- Preclinical investigation
- Rats
ASJC Scopus subject areas
- Toxicology
- Pharmacology
Cite this
Preclinical investigation of general toxicity of a new injection preparation of A(1,2)-L-rhamno-A(1,4)-D-galactopyranozyluronane from Acorus calamus L. / Lopatina, K. A.; Churin, A. A.; Gur'ev, A. M.; Zueva, E. P.; Fomina, T. I.; Vetoshkina, T. I.; Dubskaya, T. Yu; Lamzina, T. Yu; Sadrikina, L. A.; Fedorova, E. P.; Neupokoeva, O. V.; Safonova, E. A.; Razina, T. G.; Krylova, S. G.; Amosova, E. N.; Rybalkina, O. Yu; Belousov, M. V.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 82, No. 2, 01.01.2019, p. 21-24.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Preclinical investigation of general toxicity of a new injection preparation of A(1,2)-L-rhamno-A(1,4)-D-galactopyranozyluronane from Acorus calamus L.
AU - Lopatina, K. A.
AU - Churin, A. A.
AU - Gur'ev, A. M.
AU - Zueva, E. P.
AU - Fomina, T. I.
AU - Vetoshkina, T. I.
AU - Dubskaya, T. Yu
AU - Lamzina, T. Yu
AU - Sadrikina, L. A.
AU - Fedorova, E. P.
AU - Neupokoeva, O. V.
AU - Safonova, E. A.
AU - Razina, T. G.
AU - Krylova, S. G.
AU - Amosova, E. N.
AU - Rybalkina, O. Yu
AU - Belousov, M. V.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The acute and chronic toxicity of a new preparation of a(1,2)-L-rhamno-a(1,4)-D-galactopyranozyluronane from Acorus calamus L. intended for antitumor therapy was studied at the stage of preclinical research. As a result of acute experiments, it was established that the drug administration in the maximum permissible amount had no toxic effects on test animals (rats and mice). The study of chronic toxicity showed that the new drug intraperitoneally administered in doses of 20,100 and 200 mg/kg for three months did not cause death of animals or any pathological changes of their general condition, body weight dynamics, and functional activity of internal organs and systems. Clinical and laboratory parameters in animals during chronic experiments did not differ from those in healthy animals. Some dose-dependent local irritation was observed.
AB - The acute and chronic toxicity of a new preparation of a(1,2)-L-rhamno-a(1,4)-D-galactopyranozyluronane from Acorus calamus L. intended for antitumor therapy was studied at the stage of preclinical research. As a result of acute experiments, it was established that the drug administration in the maximum permissible amount had no toxic effects on test animals (rats and mice). The study of chronic toxicity showed that the new drug intraperitoneally administered in doses of 20,100 and 200 mg/kg for three months did not cause death of animals or any pathological changes of their general condition, body weight dynamics, and functional activity of internal organs and systems. Clinical and laboratory parameters in animals during chronic experiments did not differ from those in healthy animals. Some dose-dependent local irritation was observed.
KW - Acorus calamus L
KW - Acute toxicity
KW - Chronic toxicity
KW - Mice
KW - Polysaccharides
KW - Preclinical investigation
KW - Rats
UR - http://www.scopus.com/inward/record.url?scp=85068825412&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068825412&partnerID=8YFLogxK
U2 - 10.30906/0869-2092-2019-82-2-21-24
DO - 10.30906/0869-2092-2019-82-2-21-24
M3 - Article
AN - SCOPUS:85068825412
VL - 82
SP - 21
EP - 24
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 2
ER -