Practical synthesis of amides from in situ generated copper(I) acetylides and sulfonyl azides

Michael P. Cassidy, Jessica Raushel, Valery V. Fokin

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

(Chemical Equation Presented) A direct, simple, and efficient route from terminal alkynes to amides is achieved by their copper(I)-catalyzed reaction with sulfonyl azides (see scheme). The reaction proceeds with the in situ generation of copper(I) acetylides and represents a one-step formal oxidative hydration of a triple bond.

Original languageEnglish
Pages (from-to)3154-3157
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number19
DOIs
Publication statusPublished - 5 May 2006
Externally publishedYes

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Keywords

  • Alkynes
  • Azides
  • Copper
  • Oxidation
  • Synthetic methods

ASJC Scopus subject areas

  • Chemistry(all)

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