Abstract
(Chemical Equation Presented) A direct, simple, and efficient route from terminal alkynes to amides is achieved by their copper(I)-catalyzed reaction with sulfonyl azides (see scheme). The reaction proceeds with the in situ generation of copper(I) acetylides and represents a one-step formal oxidative hydration of a triple bond.
| Original language | English |
|---|---|
| Pages (from-to) | 3154-3157 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 45 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 5 May 2006 |
| Externally published | Yes |
Keywords
- Alkynes
- Azides
- Copper
- Oxidation
- Synthetic methods
ASJC Scopus subject areas
- Chemistry(all)
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Cite this
Cassidy, M. P., Raushel, J., & Fokin, V. V. (2006). Practical synthesis of amides from in situ generated copper(I) acetylides and sulfonyl azides. Angewandte Chemie - International Edition, 45(19), 3154-3157. https://doi.org/10.1002/anie.200503805