Abstract
(Chemical Equation Presented) A direct, simple, and efficient route from terminal alkynes to amides is achieved by their copper(I)-catalyzed reaction with sulfonyl azides (see scheme). The reaction proceeds with the in situ generation of copper(I) acetylides and represents a one-step formal oxidative hydration of a triple bond.
| Original language | English |
|---|---|
| Pages (from-to) | 3154-3157 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 45 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 5 May 2006 |
| Externally published | Yes |
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Keywords
- Alkynes
- Azides
- Copper
- Oxidation
- Synthetic methods
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Practical synthesis of amides from in situ generated copper(I) acetylides and sulfonyl azides. / Cassidy, Michael P.; Raushel, Jessica; Fokin, Valery V.
In: Angewandte Chemie - International Edition, Vol. 45, No. 19, 05.05.2006, p. 3154-3157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Practical synthesis of amides from in situ generated copper(I) acetylides and sulfonyl azides
AU - Cassidy, Michael P.
AU - Raushel, Jessica
AU - Fokin, Valery V.
PY - 2006/5/5
Y1 - 2006/5/5
N2 - (Chemical Equation Presented) A direct, simple, and efficient route from terminal alkynes to amides is achieved by their copper(I)-catalyzed reaction with sulfonyl azides (see scheme). The reaction proceeds with the in situ generation of copper(I) acetylides and represents a one-step formal oxidative hydration of a triple bond.
AB - (Chemical Equation Presented) A direct, simple, and efficient route from terminal alkynes to amides is achieved by their copper(I)-catalyzed reaction with sulfonyl azides (see scheme). The reaction proceeds with the in situ generation of copper(I) acetylides and represents a one-step formal oxidative hydration of a triple bond.
KW - Alkynes
KW - Azides
KW - Copper
KW - Oxidation
KW - Synthetic methods
UR - http://www.scopus.com/inward/record.url?scp=33746191914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746191914&partnerID=8YFLogxK
U2 - 10.1002/anie.200503805
DO - 10.1002/anie.200503805
M3 - Article
C2 - 16570330
AN - SCOPUS:33746191914
VL - 45
SP - 3154
EP - 3157
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 19
ER -