Postconditioning the heart: Analysis of experimental and clinical data

L. N. Maslov, S. Yu Tsibul'Nikov, A. V. Mukhomedzyanov, A. S. Sementsov, A. V. Tsepokina, M. V. Khutornaya, A. G. Kutikhin, I. F. Nam

Research output: Contribution to journalArticle

Abstract

Experimental atherosclerosis and hypercholesterolemia may reduce or eliminate the infarct-limiting and anti-apoptotic effect of postconditioning (PC). Experiments in rats and mice indicate that the PC may be quite effective in patients with diabetes type 2 or metabolic syndrome. Experimental data suggest that hypertension or the past myocardial infarction is not an obstacle for the implementation of cardioprotective effect of PC. It was established that that aging does not preclude the implementation of PC cardioprotective effect. Inotropic effect of IP can simulate on isolated human atrial trabeculae. The clinical observations suggest that the PC in patients with tetralogy of Fallot and patients with operations on the valves improves the outcome of cardiac surgery. It was established that PC in these patients reduces the intensity of reperfusion necrosis of cardiomyocytes, improves the pumping function of the heart, reduces the inotropic support, shorten the extubation time.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalVestnik Rossiiskoi Akademii Meditsinskikh Nauk
Volume71
Issue number1
DOIs
Publication statusPublished - 2016

Keywords

  • Heart
  • Ischemia
  • Postconditioning
  • Reperfusion

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Maslov, L. N., Tsibul'Nikov, S. Y., Mukhomedzyanov, A. V., Sementsov, A. S., Tsepokina, A. V., Khutornaya, M. V., Kutikhin, A. G., & Nam, I. F. (2016). Postconditioning the heart: Analysis of experimental and clinical data. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, 71(1), 25-30. https://doi.org/10.15690/vramn628