Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart

Yu B. Lishmanov, L. N. Maslov, A. V. Krylatov, N. V. Solenkova, D. L. Stakheev

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

During aconitine-induced arrhythmias the antiarrhythmic effect of DALDA (Tyr-D-Arg-Phe-Lys-NH2) and nociceptin (orphanin FQ) administered intravenously depended on activation of nitric oxide synthase. KATP channels were not involved in the realization of this effect. Endogenous prostanoids played a minor role in the antiarrhythmic effect of nociceptin and did not contribute to the protective influence of DALDA. The antiarrhythmic effect of orphanin FQ administered intravenously did not depend on functional activity of the autonomic nervous system. However, the effect of orphanin FQ after intracerebroventricular infusion was determined by changes in the state of this system.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume135
Issue number1
DOIs
Publication statusPublished - 1 Jan 2003

Keywords

  • Arrhythmias
  • DALDA
  • Nociceptin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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