Porous inorganic carriers based on silica, calcium carbonate and calcium phosphate for controlled/modulated drug delivery

Fresh outlook and future perspectives

Alexey D. Trofimov, Anna A. Ivanova, Mikhail V. Zyuzin, Alexander S. Timin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Porous inorganic nanostructured materials are widely used nowadays as drug delivery carriers due to their adventurous features: suitable architecture, large surface area and stability in the biological fluids. Among the different types of inorganic porous materials, silica, calcium carbonate, and calcium phosphate have received significant attention in the last decade. The use of porous inorganic materials as drug carriers for cancer therapy, gene delivery etc. has the potential to improve the life expectancy of the patients affected by the disease. The main goal of this review is to provide general information on the current state of the art of synthesis of the inorganic porous particles based on silica, calcium carbonate and calcium phosphate. Special focus is dedicated to the loading capacity, controllable release of drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic field, and ultrasound). Moreover, the diverse compounds to deliver with silica, calcium carbonate and calcium phosphate particles, ranging from the commercial drugs to genetic materials are also discussed.

Original languageEnglish
Pages (from-to)1.-35
JournalPharmaceutics
Volume10
Issue number4
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

Calcium Carbonate
Silicon Dioxide
Drug Carriers
Pharmaceutical Preparations
Synthetic Chemistry Techniques
Nanostructures
Neoplasm Genes
Magnetic Fields
Life Expectancy
Oxidation-Reduction
Light
Enzymes
Genes
calcium phosphate
Therapeutics

Keywords

  • Calcium carbonate
  • Calcium phosphate
  • Drug delivery systems
  • Drug loading
  • In vitro and in vivo delivery
  • Silica-based particles

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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AU - Zyuzin, Mikhail V.

AU - Timin, Alexander S.

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N2 - Porous inorganic nanostructured materials are widely used nowadays as drug delivery carriers due to their adventurous features: suitable architecture, large surface area and stability in the biological fluids. Among the different types of inorganic porous materials, silica, calcium carbonate, and calcium phosphate have received significant attention in the last decade. The use of porous inorganic materials as drug carriers for cancer therapy, gene delivery etc. has the potential to improve the life expectancy of the patients affected by the disease. The main goal of this review is to provide general information on the current state of the art of synthesis of the inorganic porous particles based on silica, calcium carbonate and calcium phosphate. Special focus is dedicated to the loading capacity, controllable release of drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic field, and ultrasound). Moreover, the diverse compounds to deliver with silica, calcium carbonate and calcium phosphate particles, ranging from the commercial drugs to genetic materials are also discussed.

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