Polytriazoles as copper(I)-stabilizing ligands in catalysis

Timothy R. Chan, Robert Hilgraf, K. Barry Sharpless, Valery V. Fokin

Research output: Contribution to journalArticle

1199 Citations (Scopus)

Abstract

(Equation Presented) Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.

Original languageEnglish
Pages (from-to)2853-2855
Number of pages3
JournalOrganic Letters
Volume6
Issue number17
DOIs
Publication statusPublished - 19 Aug 2004
Externally publishedYes

Fingerprint

Catalysis
catalysis
Copper
Ligands
copper
ligands
Alkynes
Azides
alkynes
Ligation
catalytic activity
Catalyst activity
Derivatives
Oxidation
oxidation
titanocene bis(trichloroacetate)

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Chan, T. R., Hilgraf, R., Sharpless, K. B., & Fokin, V. V. (2004). Polytriazoles as copper(I)-stabilizing ligands in catalysis. Organic Letters, 6(17), 2853-2855. https://doi.org/10.1021/ol0493094

Polytriazoles as copper(I)-stabilizing ligands in catalysis. / Chan, Timothy R.; Hilgraf, Robert; Sharpless, K. Barry; Fokin, Valery V.

In: Organic Letters, Vol. 6, No. 17, 19.08.2004, p. 2853-2855.

Research output: Contribution to journalArticle

Chan, TR, Hilgraf, R, Sharpless, KB & Fokin, VV 2004, 'Polytriazoles as copper(I)-stabilizing ligands in catalysis', Organic Letters, vol. 6, no. 17, pp. 2853-2855. https://doi.org/10.1021/ol0493094
Chan TR, Hilgraf R, Sharpless KB, Fokin VV. Polytriazoles as copper(I)-stabilizing ligands in catalysis. Organic Letters. 2004 Aug 19;6(17):2853-2855. https://doi.org/10.1021/ol0493094
Chan, Timothy R. ; Hilgraf, Robert ; Sharpless, K. Barry ; Fokin, Valery V. / Polytriazoles as copper(I)-stabilizing ligands in catalysis. In: Organic Letters. 2004 ; Vol. 6, No. 17. pp. 2853-2855.
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