Polytriazoles as copper(I)-stabilizing ligands in catalysis

Timothy R. Chan, Robert Hilgraf, K. Barry Sharpless, Valery V. Fokin

Research output: Contribution to journalArticlepeer-review

1254 Citations (Scopus)

Abstract

(Equation Presented) Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.

Original languageEnglish
Pages (from-to)2853-2855
Number of pages3
JournalOrganic Letters
Volume6
Issue number17
DOIs
Publication statusPublished - 19 Aug 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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