Polysaccharides of tussilago farfara L. As components of chemotherapy scheme

E. A. Safonova, K. A. Lopatina, E. P. Fedorova, O. Yu Rybalkina, T. G. Razina, A. M. Guriev, M. V. Belousov, E. P. Zueva

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

It was found that the addition of polysaccharides of Tussilago farfara L. to chemotherapy scheme "cisplatin + etoposide" lead to more pronounced inhibition of the Lewis lung carcinoma growth in mice due to the reduction of its mass in comparison with these parameters in animals treated according to the same scheme isolated. A use of polysaccharides of Tussilago farfara L. could reduce the hematotoxic effect of polychemotherapy with the "cisplatin + etoposide" scheme, which was expressed in a decrease of leukopenia and anemia.

Original language	English
Pages (from-to)	798-801
Number of pages	4
Journal	Voprosy Onkologii
Volume	63
Issue number	5
Publication status	Published - 1 Jan 2017

Keywords

Cisplatin
Etoposide
Lewis lung carcinoma
Polychemotherapy
Polysaccharides

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Polysaccharides of tussilago farfara L. As components of chemotherapy scheme",

abstract = "It was found that the addition of polysaccharides of Tussilago farfara L. to chemotherapy scheme {"}cisplatin + etoposide{"} lead to more pronounced inhibition of the Lewis lung carcinoma growth in mice due to the reduction of its mass in comparison with these parameters in animals treated according to the same scheme isolated. A use of polysaccharides of Tussilago farfara L. could reduce the hematotoxic effect of polychemotherapy with the {"}cisplatin + etoposide{"} scheme, which was expressed in a decrease of leukopenia and anemia.",

keywords = "Cisplatin, Etoposide, Lewis lung carcinoma, Polychemotherapy, Polysaccharides",

author = "Safonova, {E. A.} and Lopatina, {K. A.} and Fedorova, {E. P.} and Rybalkina, {O. Yu} and Razina, {T. G.} and Guriev, {A. M.} and Belousov, {M. V.} and Zueva, {E. P.}",

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language = "English",

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pages = "798--801",

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TY - JOUR

T1 - Polysaccharides of tussilago farfara L. As components of chemotherapy scheme

AU - Safonova, E. A.

AU - Lopatina, K. A.

AU - Fedorova, E. P.

AU - Rybalkina, O. Yu

AU - Razina, T. G.

AU - Guriev, A. M.

AU - Belousov, M. V.

AU - Zueva, E. P.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - It was found that the addition of polysaccharides of Tussilago farfara L. to chemotherapy scheme "cisplatin + etoposide" lead to more pronounced inhibition of the Lewis lung carcinoma growth in mice due to the reduction of its mass in comparison with these parameters in animals treated according to the same scheme isolated. A use of polysaccharides of Tussilago farfara L. could reduce the hematotoxic effect of polychemotherapy with the "cisplatin + etoposide" scheme, which was expressed in a decrease of leukopenia and anemia.

AB - It was found that the addition of polysaccharides of Tussilago farfara L. to chemotherapy scheme "cisplatin + etoposide" lead to more pronounced inhibition of the Lewis lung carcinoma growth in mice due to the reduction of its mass in comparison with these parameters in animals treated according to the same scheme isolated. A use of polysaccharides of Tussilago farfara L. could reduce the hematotoxic effect of polychemotherapy with the "cisplatin + etoposide" scheme, which was expressed in a decrease of leukopenia and anemia.

KW - Cisplatin

KW - Etoposide

KW - Lewis lung carcinoma

KW - Polychemotherapy

KW - Polysaccharides

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