Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material

O. Lyutakov, O. Hejna, A. Solovyev, Y. Kalachyova, V. Svorcik

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Light-activated antimicrobial materials based on polymethylmethacrylate doped with porphyrin and silver nanoparticles were prepared and studied. The inspiration for the material design originates from photodynamic therapy where light is used to destroy pathogen microbes. Antimicrobial response of the materials is controlled by blue light illumination. Porphyrin molecules serve as light absorbers with dual antimicrobial response under illumination they produce reactive oxygen and affect the kinetics of silver release from the polymer. Silver is responsive for the antimicrobial effect, for the protection of porphyrin against photobleaching and for the conservation of energy through suppression of porphyrin luminescence. Triggerable and enhanced antimicrobial response of the material is activated through several possible mechanisms, including local heating of the polymer matrix, transfer of the excited state from porphyrin to silver and the synergetic effect of reactive oxygen and silver. In a passive state the material exhibits weak antimicrobial response against Gram-negative bacteria. In an active state, however, it is fatal for both Gram negative and Gram positive bacteria.

Original languageEnglish
Pages (from-to)50624-50630
Number of pages7
JournalRSC Advances
Volume4
Issue number92
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Fingerprint

Porphyrins
Polymethyl Methacrylate
Silver
Nanoparticles
Bacteria
Lighting
Oxygen
Photobleaching
Photodynamic therapy
Pathogens
Polymer matrix
Excited states
Luminescence
Conservation
Polymers
Heating
Molecules
Kinetics

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material. / Lyutakov, O.; Hejna, O.; Solovyev, A.; Kalachyova, Y.; Svorcik, V.

In: RSC Advances, Vol. 4, No. 92, 01.01.2014, p. 50624-50630.

Research output: Contribution to journalArticle

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