Abstract
Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.
| Original language | English |
|---|---|
| Pages (from-to) | 1274-1279 |
| Number of pages | 6 |
| Journal | QSAR and Combinatorial Science |
| Volume | 26 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - Dec 2007 |
| Externally published | Yes |
Fingerprint
Keywords
- Alkynes
- Azides
- Catalysis
- Click chemistry
- Cycloaddition
ASJC Scopus subject areas
- Discrete Mathematics and Combinatorics
- Pharmacology
Cite this
Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition. / Chan, Timothy R.; Fokin, Valery V.
In: QSAR and Combinatorial Science, Vol. 26, No. 11-12, 12.2007, p. 1274-1279.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition
AU - Chan, Timothy R.
AU - Fokin, Valery V.
PY - 2007/12
Y1 - 2007/12
N2 - Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.
AB - Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.
KW - Alkynes
KW - Azides
KW - Catalysis
KW - Click chemistry
KW - Cycloaddition
UR - http://www.scopus.com/inward/record.url?scp=37549048155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37549048155&partnerID=8YFLogxK
U2 - 10.1002/qsar.200740131
DO - 10.1002/qsar.200740131
M3 - Article
VL - 26
SP - 1274
EP - 1279
JO - QSAR and Combinatorial Science
JF - QSAR and Combinatorial Science
SN - 1611-020X
IS - 11-12
ER -