Abstract
Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.
| Original language | English |
|---|---|
| Pages (from-to) | 1274-1279 |
| Number of pages | 6 |
| Journal | QSAR and Combinatorial Science |
| Volume | 26 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - Dec 2007 |
| Externally published | Yes |
Keywords
- Alkynes
- Azides
- Catalysis
- Click chemistry
- Cycloaddition
ASJC Scopus subject areas
- Discrete Mathematics and Combinatorics
- Pharmacology
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Cite this
Chan, T. R., & Fokin, V. V. (2007). Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition. QSAR and Combinatorial Science, 26(11-12), 1274-1279. https://doi.org/10.1002/qsar.200740131