Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition

Abstract

Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.

Original language	English
Pages (from-to)	1274-1279
Number of pages	6
Journal	QSAR and Combinatorial Science
Volume	26
Issue number	11-12
DOIs	https://doi.org/10.1002/qsar.200740131
Publication status	Published - Dec 2007
Externally published	Yes

Keywords

Alkynes
Azides
Catalysis
Click chemistry
Cycloaddition

ASJC Scopus subject areas

Discrete Mathematics and Combinatorics
Pharmacology

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10.1002/qsar.200740131

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title = "Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition",

abstract = "Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.",

keywords = "Alkynes, Azides, Catalysis, Click chemistry, Cycloaddition",

author = "Chan, {Timothy R.} and Fokin, {Valery V.}",

year = "2007",

month = dec,

doi = "10.1002/qsar.200740131",

language = "English",

volume = "26",

pages = "1274--1279",

journal = "QSAR and Combinatorial Science",

issn = "1611-020X",

publisher = "Wiley - VCH Verlag GmbH & CO. KGaA",

number = "11-12",

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T1 - Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition

AU - Chan, Timothy R.

AU - Fokin, Valery V.

PY - 2007/12

Y1 - 2007/12

N2 - Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.

AB - Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.

KW - Alkynes

KW - Azides

KW - Catalysis

KW - Click chemistry

KW - Cycloaddition

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DO - 10.1002/qsar.200740131

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SP - 1274

EP - 1279

JO - QSAR and Combinatorial Science

JF - QSAR and Combinatorial Science

SN - 1611-020X

IS - 11-12