Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition

Timothy R. Chan, Valery V. Fokin

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77 Citations (Scopus)

Abstract

Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.

Original languageEnglish
Pages (from-to)1274-1279
Number of pages6
JournalQSAR and Combinatorial Science
Volume26
Issue number11-12
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

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Keywords

  • Alkynes
  • Azides
  • Catalysis
  • Click chemistry
  • Cycloaddition

ASJC Scopus subject areas

  • Discrete Mathematics and Combinatorics
  • Pharmacology

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