Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition

Timothy R. Chan, Valery V. Fokin

Research output: Contribution to journal › Article

Abstract

Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.

Original language	English
Pages (from-to)	1274-1279
Number of pages	6
Journal	QSAR and Combinatorial Science
Volume	26
Issue number	11-12
DOIs	https://doi.org/10.1002/qsar.200740131
Publication status	Published - Dec 2007
Externally published	Yes

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Keywords

Alkynes
Azides
Catalysis
Click chemistry
Cycloaddition

ASJC Scopus subject areas

Discrete Mathematics and Combinatorics
Pharmacology

Cite this

Chan, T. R., & Fokin, V. V. (2007). Polymer-supported copper(I) catalysts for the experimentally simplified azide-alkyne cycloaddition. QSAR and Combinatorial Science, 26(11-12), 1274-1279. https://doi.org/10.1002/qsar.200740131

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Access to Document

10.1002/qsar.200740131