TY - JOUR
T1 - Polymer capsules modified with iron oxide nanoparticles as an effective platform for MRI visualization and drug delivery
AU - Fatkhutdinova, L. I.
AU - Andreychenko, A.
AU - Brui, E.
AU - Timin, A. S.
AU - Pavlovskaya, G. E.
AU - Khlobystov, A. N.
AU - Zyuzin, M. V.
PY - 2020/4/23
Y1 - 2020/4/23
N2 - Efficiency of existing (usually toxic) drugs can be increased substantially with the targeted effect on the site of the disease. A potential platform for the targeted drug delivery can be polymer capsules. This will help reduce side effects on the human body and start treatment at the early stages of the disease. Modification of such capsules with the magnetic nanoparticles allows their visualization using magnetic resonance imaging (MRI). In this study the use of polymer microcapsules modified with iron oxide nanoparticles are employed as contrast agents for T2-weighted magnetic resonance (MR) images, the possibility of their implementation as for drug delivery carriers are discussed. For this, two different types of polymer capsules are synthesized. The results on the spin-spin and spin-lattice relaxivities were obtained.
AB - Efficiency of existing (usually toxic) drugs can be increased substantially with the targeted effect on the site of the disease. A potential platform for the targeted drug delivery can be polymer capsules. This will help reduce side effects on the human body and start treatment at the early stages of the disease. Modification of such capsules with the magnetic nanoparticles allows their visualization using magnetic resonance imaging (MRI). In this study the use of polymer microcapsules modified with iron oxide nanoparticles are employed as contrast agents for T2-weighted magnetic resonance (MR) images, the possibility of their implementation as for drug delivery carriers are discussed. For this, two different types of polymer capsules are synthesized. The results on the spin-spin and spin-lattice relaxivities were obtained.
UR - http://www.scopus.com/inward/record.url?scp=85084149443&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084149443&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/1461/1/012037
DO - 10.1088/1742-6596/1461/1/012037
M3 - Conference article
AN - SCOPUS:85084149443
VL - 1461
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
SN - 1742-6588
IS - 1
M1 - 012037
T2 - 4th International Conference on Metamaterials and Nanophotonics, METANANO 2019
Y2 - 15 July 2019 through 19 July 2019
ER -