Polylactic acid sealed polyelectrolyte complex microcontainers for controlled encapsulation and NIR-Laser based release of cargo

Meiyu Gai, Wenhao Li, Johannes Frueh, Gleb B. Sukhorukov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Surface mediated drug delivery is important for a large variety of applications, especially in medicine to control cell growth, prevent blood platelet activation on implants or for self-disinfecting devices (e.g. catheters). In industrial applications, controlled release of substances from surfaces is needed in a broad range of applications from anti-corrosion systems to anti-biofouling. Polyelectrolyte multilayers (PEM) based microcontainers (MCs) require several days production time, while MCs composed out of polylactic acid (PLA) are entirely hydrophobic, offering no functionality. We hereby present an approach to fabricate PLA coated synthetic as well as biopolymer based biodegradable polyelectrolyte complex MCs able to encapsulate small hydrophilic cargo within less than one hour. The chambers facilitate laser controlled release of cargo within submerged conditions.

Original languageEnglish
Pages (from-to)521-528
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume173
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Controlled release
  • NIR-Laser
  • Polyelectrolyte complex
  • Polylactic acid
  • Small hydrophilic molecules

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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