Polylactic acid properties after steam sterilization and possibility of its using as a corneal implant

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this research is the study of the influence of thin polylactic acid (PLA) films implantation on the corneal morphology in vivo experiment. Studies were performed on 8 pubescent female Sylvilagus bachmani rabbits. PLA films were implanted into the anterior chamber of one animal eye. The feedstock for the films was obtained by dissolving PLA in the chloroform. Before the implantation PLA films were sterilized. The overall duration of the in vivo experiment comprised 21 days. Such methods as visual check, photographic registration, non-contact ocular tonometry and optical coherent tomography of cornea were also used in course of the experiment. Sampling was performed on day 21 after the start of the experiment for morphology studying. Results showed that the implantation of the PLA films into the anterior chamber of eye does not induce an inflammatory reaction and does not increase an intraocular pressure. The study showed the possibility of PLA films using as a corneal implant.

Original languageEnglish
Title of host publicationProceedings of the International Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2019
EditorsVictor E. Panin, Sergey G. Psakhie, Vasily M. Fomin
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419124
DOIs
Publication statusPublished - 19 Nov 2019
EventInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2019 - Tomsk, Russian Federation
Duration: 1 Oct 20195 Oct 2019

Publication series

NameAIP Conference Proceedings
Volume2167
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2019
CountryRussian Federation
CityTomsk
Period1.10.195.10.19

    Fingerprint

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Filippova, E. O., & Ivanova, N. M. (2019). Polylactic acid properties after steam sterilization and possibility of its using as a corneal implant. In V. E. Panin, S. G. Psakhie, & V. M. Fomin (Eds.), Proceedings of the International Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2019 [020104] (AIP Conference Proceedings; Vol. 2167). American Institute of Physics Inc.. https://doi.org/10.1063/1.5131971