Abstract
The purpose of this research is the study of the influence of thin polylactic acid films implantation on the corneal morphology in vivo experiment. Studies were performed on 8 pubescent female Sylvilagus bachmani rabbits. Polylactic acid films were implanted into the anterior chamber of one animal eye. The feedstock for the films was obtained by dissolving polylactic acid in the chloroform. Before the implantation PLA films were sterilized. The overall duration of the in vivo experiment comprised 21 days. Such methods as visual check, photographic registration, non-contact ocular tonometry and optical coherent tomography of cornea were also used in course of the experiment. Sampling was performed on day 21 after the start of the experiment for morphology studying. Results showed that the implantation of the PLA films into the anterior chamber of eye does not induce an inflammatory reaction and does not increase an intraocular pressure. The study showed the possibility of PLA films using as a corneal implant.
| Original language | English |
|---|---|
| Article number | 012066 |
| Journal | IOP Conference Series: Materials Science and Engineering |
| Volume | 597 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 23 Aug 2019 |
| Event | 16th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2019 - Tomsk, Russian Federation Duration: 23 Apr 2019 → 26 Apr 2019 |
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ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
Cite this
Polylactic acid films implantation into the anterior chamber of eye in vivo. / Filippova, E. O.; Ivanova, N. M.; Pichugin, V. F.; Sun, Z.
In: IOP Conference Series: Materials Science and Engineering, Vol. 597, No. 1, 012066, 23.08.2019.Research output: Contribution to journal › Conference article
}
TY - JOUR
T1 - Polylactic acid films implantation into the anterior chamber of eye in vivo
AU - Filippova, E. O.
AU - Ivanova, N. M.
AU - Pichugin, V. F.
AU - Sun, Z.
PY - 2019/8/23
Y1 - 2019/8/23
N2 - The purpose of this research is the study of the influence of thin polylactic acid films implantation on the corneal morphology in vivo experiment. Studies were performed on 8 pubescent female Sylvilagus bachmani rabbits. Polylactic acid films were implanted into the anterior chamber of one animal eye. The feedstock for the films was obtained by dissolving polylactic acid in the chloroform. Before the implantation PLA films were sterilized. The overall duration of the in vivo experiment comprised 21 days. Such methods as visual check, photographic registration, non-contact ocular tonometry and optical coherent tomography of cornea were also used in course of the experiment. Sampling was performed on day 21 after the start of the experiment for morphology studying. Results showed that the implantation of the PLA films into the anterior chamber of eye does not induce an inflammatory reaction and does not increase an intraocular pressure. The study showed the possibility of PLA films using as a corneal implant.
AB - The purpose of this research is the study of the influence of thin polylactic acid films implantation on the corneal morphology in vivo experiment. Studies were performed on 8 pubescent female Sylvilagus bachmani rabbits. Polylactic acid films were implanted into the anterior chamber of one animal eye. The feedstock for the films was obtained by dissolving polylactic acid in the chloroform. Before the implantation PLA films were sterilized. The overall duration of the in vivo experiment comprised 21 days. Such methods as visual check, photographic registration, non-contact ocular tonometry and optical coherent tomography of cornea were also used in course of the experiment. Sampling was performed on day 21 after the start of the experiment for morphology studying. Results showed that the implantation of the PLA films into the anterior chamber of eye does not induce an inflammatory reaction and does not increase an intraocular pressure. The study showed the possibility of PLA films using as a corneal implant.
UR - http://www.scopus.com/inward/record.url?scp=85073592633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073592633&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/597/1/012066
DO - 10.1088/1757-899X/597/1/012066
M3 - Conference article
AN - SCOPUS:85073592633
VL - 597
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
SN - 1757-8981
IS - 1
M1 - 012066
ER -