The purpose of this research is the study of the influence of thin polylactic acid films implantation on the corneal morphology in vivo experiment. Studies were performed on 8 pubescent female Sylvilagus bachmani rabbits. Polylactic acid films were implanted into the anterior chamber of one animal eye. The feedstock for the films was obtained by dissolving polylactic acid in the chloroform. Before the implantation PLA films were sterilized. The overall duration of the in vivo experiment comprised 21 days. Such methods as visual check, photographic registration, non-contact ocular tonometry and optical coherent tomography of cornea were also used in course of the experiment. Sampling was performed on day 21 after the start of the experiment for morphology studying. Results showed that the implantation of the PLA films into the anterior chamber of eye does not induce an inflammatory reaction and does not increase an intraocular pressure. The study showed the possibility of PLA films using as a corneal implant.
|Journal||IOP Conference Series: Materials Science and Engineering|
|Publication status||Published - 23 Aug 2019|
|Event||16th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2019 - Tomsk, Russian Federation|
Duration: 23 Apr 2019 → 26 Apr 2019
ASJC Scopus subject areas
- Materials Science(all)