Abstract
Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.
Original language | English |
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Pages (from-to) | 913-935 |
Number of pages | 23 |
Journal | Collection of Czechoslovak Chemical Communications |
Volume | 67 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jul 2002 |
Externally published | Yes |
Keywords
- I
- At
- Br
- Boranes
- Carboranes
- Isotope labelling
- Polyhedral boron clusters
- Prosthetic groups
- Tumour targeting
ASJC Scopus subject areas
- Chemistry(all)