Polyhedral boron compounds as potential linkers for attachment of radiohalogens to targeting proteins and peptides. A review

Abstract

Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.

Original language	English
Pages (from-to)	913-935
Number of pages	23
Journal	Collection of Czechoslovak Chemical Communications
Volume	67
Issue number	7
DOIs	https://doi.org/10.1135/cccc20020913
Publication status	Published - 1 Jul 2002
Externally published	Yes

Keywords

I
At
Br
Boranes
Carboranes
Isotope labelling
Polyhedral boron clusters
Prosthetic groups
Tumour targeting

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1135/cccc20020913

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title = "Polyhedral boron compounds as potential linkers for attachment of radiohalogens to targeting proteins and peptides. A review",

abstract = "Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.",

keywords = "I, At, Br, Boranes, Carboranes, Isotope labelling, Polyhedral boron clusters, Prosthetic groups, Tumour targeting",

author = "Vladimir Tolmachev and Stefan Sj{\"o}berg",

year = "2002",

month = jul,

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AU - Tolmachev, Vladimir

AU - Sjöberg, Stefan

PY - 2002/7/1

Y1 - 2002/7/1

N2 - Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.

AB - Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.

KW - I

KW - At

KW - Br

KW - Boranes

KW - Carboranes

KW - Isotope labelling

KW - Polyhedral boron clusters

KW - Prosthetic groups

KW - Tumour targeting

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EP - 935

JO - Collection of Czechoslovak Chemical Communications

JF - Collection of Czechoslovak Chemical Communications

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