Polyhedral boron compounds as potential linkers for attachment of radiohalogens to targeting proteins and peptides. A review

Vladimir Tolmachev, Stefan Sjöberg

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)

Abstract

Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.

Original languageEnglish
Pages (from-to)913-935
Number of pages23
JournalCollection of Czechoslovak Chemical Communications
Volume67
Issue number7
DOIs
Publication statusPublished - 1 Jul 2002
Externally publishedYes

Keywords

  • I
  • At
  • Br
  • Boranes
  • Carboranes
  • Isotope labelling
  • Polyhedral boron clusters
  • Prosthetic groups
  • Tumour targeting

ASJC Scopus subject areas

  • Chemistry(all)

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