Polyacrylate guanidine and polymethacrylate guanidine as novel cationic polymers for effective bilirubin binding

Alexander S. Timin, Alexey V. Solomonov, Evgeniy V. Rumyantsev

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effect of polycationic polymers of polyacrylate guanidine (PAG) and polymethacrylate guanidine (PMAG) on bilirubin absorbance were studied in phosphate buffer (pH 7.4). It was shown that the change in absorbance spectra of bilirubin in the presence of PAG/PMAG can be associated with the formation of a bilirubin-polymer complex and dissociation of tetramers on bilirubin monomers. Also, the organicinorganic composite materials based on silica gels and guanidine polymers were synthesized via the sol-gel technique. The incorporated guanidine polymers have a big influence on particle size distribution of silica gel due to their high crosslinking ability. The infrared spectroscopy revealed the presence of guanidine polymers inside solid networks of silica gel. The bilirubin adsorption process onto a guanidine functionalized silica surface was investigated. The Langmuir and Redlich-Peterson isotherm models were tested to explain the adsorption mechanism. The analysis of the adsorption isotherms confirms the possibility of electrostatic interactions of bilirubin molecules with guanidine polymers incorporated inside silica matrix. We conclude that cationic guanidine polymers might be effectively applied for bilirubin removal.

Original languageEnglish
Article number400
JournalJournal of Polymer Research
Volume21
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Guanidine
Polyacrylates
Bilirubin
Polymers
Silica gel
Silica Gel
Silica
Silicon Dioxide
Adsorption
Coulomb interactions
polymethacrylic acid
Adsorption isotherms
Particle size analysis
Crosslinking
Sol-gels
Isotherms
Infrared spectroscopy
Phosphates
Monomers
Molecules

Keywords

  • Adsorption
  • Bilirubin
  • Complex
  • Guanidine polymers
  • Interactions
  • Sol-gel

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry

Cite this

Polyacrylate guanidine and polymethacrylate guanidine as novel cationic polymers for effective bilirubin binding. / Timin, Alexander S.; Solomonov, Alexey V.; Rumyantsev, Evgeniy V.

In: Journal of Polymer Research, Vol. 21, No. 4, 400, 2014.

Research output: Contribution to journalArticle

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