Polarographic and voltammetric determination of genotoxic nitro derivatives of quinoline using mercury electrodes

Vlastimil Vyskočil, Ivan Jiránek, Aleš Daňhel, Jiří Zima, Jiří Barek, Joseph Wang, Karolina Pecková

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Electrochemical behavior of genotoxic nitro derivatives of quinoline, namely 5-nitroquinoline (5-NQ), 6-nitroquinoline (6-NQ) and 8-nitroquinoline (8-NQ), was investigated by DC tast polarography (DCTP) and differential pulse polarography (DPP), both at a classical dropping mercury electrode (DME), and by differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV), both at a miniaturized hanging mercury drop minielectrode (HMDmE), in buffered aqueous (for 5-NQ) or aqueous-methanolic (for 6-NQ and 8-NQ) solutions. Optimum conditions were found for the determination of 5-NQ, 6-NQ and 8-NQ by DCTP at DME (with limits of quantification, L Q ≈ 9 × 10 -7, 3 × 10 -7 and 2 × 10 -6 mol l -1, respectively), by DPP at DME (L Q ≈ 1 × 10 -8, 9 × 10 -8 and 1 × 10 -7 mol l -1, respectively), by DPV at HMDmE (L Q ≈ 2 × 10 -8, 1 × 10 -7 and 1 × 10 -7 mol l -1, respectively), and by AdSDPV at HMDmE (L Q ≈ 1 × 10 -8 mol l -1 for 8-NQ; an attempt at increasing the sensitivity using AdSDPV at HMDmE was not successful for 5-NQ and 6-NQ). Practical applicability of the developed methods was verified on the direct determination of the studied compounds in model samples of drinking and river water in submicromolar concentrations and on the determination in model samples of drinking and river water using preliminary separation and preconcentration by solid phase extraction (SPE) in nanomolar concentrations.

Original languageEnglish
Pages (from-to)1991-2004
Number of pages14
JournalCollection of Czechoslovak Chemical Communications
Volume76
Issue number12
DOIs
Publication statusPublished - 1 Dec 2011
Externally publishedYes

Fingerprint

Nitroquinolines
Mercury
Derivatives
Voltammetry
Polarographic analysis
Electrodes
Rivers
quinoline
Water

Keywords

  • 5-Nitroquinoline
  • 6-Nitroquinoline
  • 8-Nitroquinoline
  • Analytical methods
  • Electrochemistry
  • Mercury electrodes
  • Polarography
  • Solid phase extraction
  • Spiked water samples
  • Voltammetry

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Polarographic and voltammetric determination of genotoxic nitro derivatives of quinoline using mercury electrodes. / Vyskočil, Vlastimil; Jiránek, Ivan; Daňhel, Aleš; Zima, Jiří; Barek, Jiří; Wang, Joseph; Pecková, Karolina.

In: Collection of Czechoslovak Chemical Communications, Vol. 76, No. 12, 01.12.2011, p. 1991-2004.

Research output: Contribution to journalArticle

Vyskočil, Vlastimil ; Jiránek, Ivan ; Daňhel, Aleš ; Zima, Jiří ; Barek, Jiří ; Wang, Joseph ; Pecková, Karolina. / Polarographic and voltammetric determination of genotoxic nitro derivatives of quinoline using mercury electrodes. In: Collection of Czechoslovak Chemical Communications. 2011 ; Vol. 76, No. 12. pp. 1991-2004.
@article{b8e25057b2844e49abd8656fe897af08,
title = "Polarographic and voltammetric determination of genotoxic nitro derivatives of quinoline using mercury electrodes",
abstract = "Electrochemical behavior of genotoxic nitro derivatives of quinoline, namely 5-nitroquinoline (5-NQ), 6-nitroquinoline (6-NQ) and 8-nitroquinoline (8-NQ), was investigated by DC tast polarography (DCTP) and differential pulse polarography (DPP), both at a classical dropping mercury electrode (DME), and by differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV), both at a miniaturized hanging mercury drop minielectrode (HMDmE), in buffered aqueous (for 5-NQ) or aqueous-methanolic (for 6-NQ and 8-NQ) solutions. Optimum conditions were found for the determination of 5-NQ, 6-NQ and 8-NQ by DCTP at DME (with limits of quantification, L Q ≈ 9 × 10 -7, 3 × 10 -7 and 2 × 10 -6 mol l -1, respectively), by DPP at DME (L Q ≈ 1 × 10 -8, 9 × 10 -8 and 1 × 10 -7 mol l -1, respectively), by DPV at HMDmE (L Q ≈ 2 × 10 -8, 1 × 10 -7 and 1 × 10 -7 mol l -1, respectively), and by AdSDPV at HMDmE (L Q ≈ 1 × 10 -8 mol l -1 for 8-NQ; an attempt at increasing the sensitivity using AdSDPV at HMDmE was not successful for 5-NQ and 6-NQ). Practical applicability of the developed methods was verified on the direct determination of the studied compounds in model samples of drinking and river water in submicromolar concentrations and on the determination in model samples of drinking and river water using preliminary separation and preconcentration by solid phase extraction (SPE) in nanomolar concentrations.",
keywords = "5-Nitroquinoline, 6-Nitroquinoline, 8-Nitroquinoline, Analytical methods, Electrochemistry, Mercury electrodes, Polarography, Solid phase extraction, Spiked water samples, Voltammetry",
author = "Vlastimil Vyskočil and Ivan Jir{\'a}nek and Aleš Daňhel and Jiř{\'i} Zima and Jiř{\'i} Barek and Joseph Wang and Karolina Peckov{\'a}",
year = "2011",
month = "12",
day = "1",
doi = "10.1135/cccc2011173",
language = "English",
volume = "76",
pages = "1991--2004",
journal = "Collection of Czechoslovak Chemical Communications",
issn = "0010-0765",
publisher = "Czech Academy of Sciences",
number = "12",

}

TY - JOUR

T1 - Polarographic and voltammetric determination of genotoxic nitro derivatives of quinoline using mercury electrodes

AU - Vyskočil, Vlastimil

AU - Jiránek, Ivan

AU - Daňhel, Aleš

AU - Zima, Jiří

AU - Barek, Jiří

AU - Wang, Joseph

AU - Pecková, Karolina

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Electrochemical behavior of genotoxic nitro derivatives of quinoline, namely 5-nitroquinoline (5-NQ), 6-nitroquinoline (6-NQ) and 8-nitroquinoline (8-NQ), was investigated by DC tast polarography (DCTP) and differential pulse polarography (DPP), both at a classical dropping mercury electrode (DME), and by differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV), both at a miniaturized hanging mercury drop minielectrode (HMDmE), in buffered aqueous (for 5-NQ) or aqueous-methanolic (for 6-NQ and 8-NQ) solutions. Optimum conditions were found for the determination of 5-NQ, 6-NQ and 8-NQ by DCTP at DME (with limits of quantification, L Q ≈ 9 × 10 -7, 3 × 10 -7 and 2 × 10 -6 mol l -1, respectively), by DPP at DME (L Q ≈ 1 × 10 -8, 9 × 10 -8 and 1 × 10 -7 mol l -1, respectively), by DPV at HMDmE (L Q ≈ 2 × 10 -8, 1 × 10 -7 and 1 × 10 -7 mol l -1, respectively), and by AdSDPV at HMDmE (L Q ≈ 1 × 10 -8 mol l -1 for 8-NQ; an attempt at increasing the sensitivity using AdSDPV at HMDmE was not successful for 5-NQ and 6-NQ). Practical applicability of the developed methods was verified on the direct determination of the studied compounds in model samples of drinking and river water in submicromolar concentrations and on the determination in model samples of drinking and river water using preliminary separation and preconcentration by solid phase extraction (SPE) in nanomolar concentrations.

AB - Electrochemical behavior of genotoxic nitro derivatives of quinoline, namely 5-nitroquinoline (5-NQ), 6-nitroquinoline (6-NQ) and 8-nitroquinoline (8-NQ), was investigated by DC tast polarography (DCTP) and differential pulse polarography (DPP), both at a classical dropping mercury electrode (DME), and by differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV), both at a miniaturized hanging mercury drop minielectrode (HMDmE), in buffered aqueous (for 5-NQ) or aqueous-methanolic (for 6-NQ and 8-NQ) solutions. Optimum conditions were found for the determination of 5-NQ, 6-NQ and 8-NQ by DCTP at DME (with limits of quantification, L Q ≈ 9 × 10 -7, 3 × 10 -7 and 2 × 10 -6 mol l -1, respectively), by DPP at DME (L Q ≈ 1 × 10 -8, 9 × 10 -8 and 1 × 10 -7 mol l -1, respectively), by DPV at HMDmE (L Q ≈ 2 × 10 -8, 1 × 10 -7 and 1 × 10 -7 mol l -1, respectively), and by AdSDPV at HMDmE (L Q ≈ 1 × 10 -8 mol l -1 for 8-NQ; an attempt at increasing the sensitivity using AdSDPV at HMDmE was not successful for 5-NQ and 6-NQ). Practical applicability of the developed methods was verified on the direct determination of the studied compounds in model samples of drinking and river water in submicromolar concentrations and on the determination in model samples of drinking and river water using preliminary separation and preconcentration by solid phase extraction (SPE) in nanomolar concentrations.

KW - 5-Nitroquinoline

KW - 6-Nitroquinoline

KW - 8-Nitroquinoline

KW - Analytical methods

KW - Electrochemistry

KW - Mercury electrodes

KW - Polarography

KW - Solid phase extraction

KW - Spiked water samples

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=84863078566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863078566&partnerID=8YFLogxK

U2 - 10.1135/cccc2011173

DO - 10.1135/cccc2011173

M3 - Article

VL - 76

SP - 1991

EP - 2004

JO - Collection of Czechoslovak Chemical Communications

JF - Collection of Czechoslovak Chemical Communications

SN - 0010-0765

IS - 12

ER -